0000000000171784

AUTHOR

Sonja Leininger

showing 2 related works from this author

Heterozygosity for the hemochromatosis gene in liver diseases - prevalence and effects on liver histology

2000

:Background/Aims: The effect of heterozygosity for the C282Y mutation in the HFE hemochromatosis gene on iron accumulation and disease progression in liver disease patients is unclear. Methods: We investigated the prevalence of this mutation in 531 patients and 205 healthy controls. In addition, we assessed the influence of the mutation on liver histology in 34 C282Y heterozygous and 124 age-, sex- and disease-matched controls without the mutation using the modified HAI and Chevallier score. Results: The highest prevalence of the C282Y mutation was observed in patients with autoimmune hepatitis (17.2%, p<0.01) compared to 6.4% in healthy controls. Heterozygotes with hepatitis C and B virus …

Hepatitismedicine.medical_specialtyHepatologybusiness.industryAutoimmune hepatitisHepatitis CHepatitis BCompound heterozygositymedicine.diseaseGastroenterologyLiver diseasePrimary biliary cirrhosisInternal medicineImmunologymedicinebusinessHemochromatosisLiver
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A new polymorphism in the human HFE gene

1999

GeneticsPolymorphism GeneticGenotypeHistocompatibility Antigens Class IHomozygoteMolecular Sequence DataImmunologyHfe geneGenes MHC Class IMembrane ProteinsExonsBiologyHuman geneticsGene FrequencyHaplotypesHLA AntigensGeneticsHumansPoint MutationHemochromatosisHemochromatosis ProteinAllelesImmunogenetics
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