0000000000172889

AUTHOR

Alexander Seeger

showing 4 related works from this author

Nationwide Analysis on Surgical Staging Procedures and Systemic Treatment for Patients With Endometrial Cancer in Germany

2012

ObjectiveIn 2009 and 2006, the Arbeitsgemeinschaft Gynäkologische Onkologie evaluated therapeutic approaches for endometrial carcinoma (EC) in Germany.Methods and MaterialsA questionnaire was developed and sent to 775 German gynecologic departments in 2009 (500 in 2006). The results of the questionnaires were compared with each other and with the recommendations of the Arbeitsgemeinschaft Gynäkologische Onkologie’s guideline. Subgroup analyses were performed, dividing the participating centers into small and large centers and into centers with less and more experience with EC.ResultsResponses were available in 33.3% in 2009 and 35.8% in 2006. Comparing 2009 with 2006, it became apparent tha…

medicine.medical_specialtyGynecologic oncologySurgical stagingGynecologic Surgical ProceduresGermanySurveys and QuestionnairesCytologyAntineoplastic Combined Chemotherapy ProtocolsmedicineCarcinomaHumansMulticenter Studies as TopicPelvic lymphadenectomyDiagnostic Techniques Obstetrical and GynecologicalNeoplasm StagingGynecologybusiness.industryData CollectionGeneral surgeryEndometrial cancerObstetrics and GynecologyProfessional PracticeGuidelinemedicine.diseaseHospitalsPeritoneal washingEndometrial NeoplasmsOncologyLymph Node ExcisionFemaleGuideline AdherencebusinessCarcinoma EndometrioidInternational Journal of Gynecologic Cancer
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345 Comparison of cisplatin and mitomycin/5-FU as radiosensitizers in the treatment of vulvar cancer – results of a single institutional cohort study

2021

Introduction/Background* Treatment of vulvar cancer contains surgery if applicable and often primary or neo-/adjuvant chemoradiation. Cisplatin and Mitomycin/5-FU are widely used radiosensitizers in vulvar cancer, although evidence is limited. We retrospectively investigated both radiosensitizers for outcome and toxicity. Methodology We screened the archive for patients treated with chemoradiation for pathologically-confirmed squamous cell cancer of the vulva between 01/2010 – 02/2021 at our institution. The impact of both radiosensitizers on prognosis was compared using Kaplan-Meier method and Cox-Regression analysis. Result(s)* 127 patients with vulvar cancer were screened. 24 patients re…

Cisplatinmedicine.medical_specialtybusiness.industrymedicine.medical_treatmentVulvar cancermedicine.diseaseGastroenterologyVulvamedicine.anatomical_structureInternal medicineToxicityMedicineStage (cooking)businessAdverse effectAdjuvantmedicine.drugCohort studyVaginal and vulvar cancer
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p53 is correlated with low BMI negative progesterone receptor status and recurring disease in patients with endometrial cancer

2011

Abstract Objective P53 tumor suppressor gene plays a role in endometrial carcinogenesis. Former studies described correlations between p53 protein overexpression in endometrial cancer and prognostic factors, measured by immunohistochemistry. But data is still controversial. The aim of this study was to measure p53 and phospho-p53 overexpression by Western blot and evaluate correlations between overexpression and prognostic and clinical factors. Phospho-p53 seems to be the functional p53 protein and was examined for the first time in endometrial cancer. Methods 40 patients with endometrial cancer were included in the study. A control group of 20 patients with normal endometrial tissue sample…

AdultOncologymedicine.medical_specialtyNegative progesterone receptorBlotting WesternKaplan-Meier EstimateDiseaseAdenocarcinomaDisease-Free SurvivalBody Mass IndexDiabetes ComplicationsWestern blotRecurrenceInternal medicineBiomarkers TumormedicineHumansIn patientPathologicalAgedAged 80 and overmedicine.diagnostic_testbusiness.industryEndometrial cancerObstetrics and GynecologyMiddle AgedGenes p53Prognosismedicine.diseaseEndometrial NeoplasmsUp-RegulationExact testOncologyCase-Control StudiesImmunohistochemistryElectrophoresis Polyacrylamide GelFemaleTumor Suppressor Protein p53Receptors ProgesteronebusinessGynecologic Oncology
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Plastische Rekonstruktion der Vagina

2018

Bei der Rekonstruktion der Vagina gilt es, verschiedene Aspekte zu berucksichtigen. Ob und auf welche Weise die Vagina nach onkologischen Eingriffen rekonstruiert werden kann, hangt von der Grose und Lokalisation des Defekts ab. Fur die Defektdeckung nach Kolpektomie eignen sich andere Verfahren als bei partiellen Defekten. Welcher Lappen oder welche Form der Rekonstruktion zum Einsatz kommen kann, ist zudem wesentlich von der onkologischen Situation sowie individuell von der Patientin und ihren Begleiterkrankungen abhangig.

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