0000000000172954
AUTHOR
M. Klemm
Two optimizing procedures for the solution of complex systems of equations: a powerful tool for modelling and simulation of metabolism
Introduction Standard calculations for the evaluation of indirect calorimetry (IC) are based on two-dimensional nonlinear systems of equations. For a more sophisticated evaluation metabolic models can be used, which are described by complex systems of equations. Since the solutions are multidimensional, a concrete result must be selected by means of constraints, using optimizing procedures. These multidimensional optimizations are critical concerning processing time and reproducibility of minimum detection. Methods In order to simulate the status of metabolism of ICU patients on the basis of IC data, a complex model of metabolism was developed. The model was described by a system of equatio…
THE TOPOLOGY OF BASIN BOUNDARIES IN A CLASS OF THREE-DIMENSIONAL DYNAMICAL SYSTEMS
We will develop new methods to determine the topology of the basin boundary in a class of three-dimensional dynamical systems. One approach is to approximate the basin boundary by backward integration. Unfortunately, there are dynamical systems where it is hard to approximate the basin boundary by a numerical backward integration algorithm. We will introduce topological methods which will provide new information about the structure of the basin boundary. The topological invariants which we will use can be numerically computed.