Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy
The tumor microenvironment (TME) is an ensemble of non-tumor cells comprising fibroblasts, cells of the immune system, and endothelial cells, besides various soluble secretory factors from all cellular components (including tumor cells). The TME forms a pro-tumorigenic cocoon around the tumor cells where reprogramming of the metabolism occurs in tumor and non-tumor cells that underlies the nature of interactions as well as competitions ensuring steady supply of nutrients and anapleoretic molecules for the tumor cells that fuels its growth even under hypoxic conditions. This metabolic reprogramming also plays a significant role in suppressing the immune attack on the tumor cells and in resis…
A Multidimensional Ethics Scale for Indian Managers' Moral Decision Making
This paper analyses the role of traditional moral theories in managers’ moral decision making using the multidimensional ethics scale (MES) developed and refined by Reidenbach and Robin (1988, 1990). This study extends their work by examining the applicability of the scale to subjects from India, other than the country in which the scale was developed. The research question is: what kind of ethical dimensions do Indian managers reveal when they are making moral decisions. Factor analysis is done to investigate the role of five moral philosophies (justice, deontology, relativism, utilitarianism, and egoism) in their ethical decision-making. The results show that the scale holds for the diffe…