0000000000175298

AUTHOR

Magalie Raveneau

showing 3 related works from this author

Liver X Receptor–Mediated Induction of Cholesteryl Ester Transfer Protein Expression Is Selectively Impaired in Inflammatory Macrophages

2009

Objective— Cholesteryl ester transfer protein (CETP) is a target gene for the liver X receptor (LXR). The aim of this study was to further explore this regulation in the monocyte-macrophage lineage and its modulation by lipid loading and inflammation, which are key steps in the process of atherogenesis. Methods and Results— Exposure of bone marrow–derived macrophages from human CETP transgenic mice to the T0901317 LXR agonist increased CETP, PLTP, and ABCA1 mRNA levels. T0901317 also markedly increased CETP mRNA levels and CETP production in human differentiated macrophages, whereas it had no effect on CETP expression in human peripheral blood monocytes. In inflammatory mouse and human mac…

030204 cardiovascular system & hematologyMonocytesMice0302 clinical medicinepolycyclic compoundsPhospholipid Transfer ProteinsCells CulturedLiver X Receptors0303 health sciencesCell DifferentiationOrphan Nuclear ReceptorsUp-RegulationLipoproteins LDLmedicine.anatomical_structureABCG1Models Animalmonocytelipids (amino acids peptides and proteins)medicine.symptomCardiology and Cardiovascular MedicineOxidation-ReductionAgonistmedicine.medical_specialtymedicine.drug_classBlotting Westerncholesteryl ester transfer proteinMice TransgenicInflammationmacrophageBiology03 medical and health sciencesDownregulation and upregulationInternal medicineCholesterylester transfer proteinmedicineAnimalsHumans[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular BiologyRNA MessengerLiver X receptorLiver X receptorProbability030304 developmental biologyMacrophagesMonocyteAtherosclerosisCholesterol Ester Transfer Proteinscarbohydrates (lipids)EndocrinologyGene Expression RegulationinflammationABCA1Immunologybiology.protein[SDV.AEN]Life Sciences [q-bio]/Food and NutritionArteriosclerosis, Thrombosis, and Vascular Biology
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Identification of biological markers of liver X receptor (LXR) activation at the cell surface of human monocytes.

2012

Background Liver X receptor (LXR) α and LXR β (NR1H3 and NR1H2) are oxysterol-activated nuclear receptors involved in the control of major metabolic pathways such as cholesterol homeostasis, lipogenesis, inflammation and innate immunity. Synthetic LXR agonists are currently under development and could find applications in various fields such as cardiovascular diseases, cancer, diabetes and neurodegenerative diseases. The clinical development of LXR agonists requires the identification of biological markers for pharmacodynamic studies. In this context, monocytes represent an attractive target to monitor LXR activation. They are easily accessible cells present in peripheral blood; they expres…

Hydrocarbons FluorinatedCD226Celllcsh:MedicineBiochemistryMonocytesDrug DiscoveryMolecular Cell Biologypolycyclic compoundsSignaling in Cellular Processeslcsh:ScienceLiver X ReceptorsSulfonamidesMultidisciplinarymedicine.diagnostic_testfood and beveragesCell DifferentiationOrphan Nuclear ReceptorsFlow CytometryNuclear SignalingCholesterolmedicine.anatomical_structureGene Knockdown Techniqueslipids (amino acids peptides and proteins)Research ArticleSignal TransductionAgonistmedicine.drug_classImmune CellsImmunologyContext (language use)Biologydigestive systemFlow cytometryAntigens CDDNA-binding proteinsmedicineHumansRNA MessengerLiver X receptorBiologyCluster of differentiationMacrophagesCell Membranelcsh:RProteinsLipid MetabolismMetabolismGene Expression RegulationNuclear receptorImmunologyCancer researchlcsh:QBiomarkersCytometryFoam CellsDevelopmental BiologyPLoS ONE
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Induction of Transglutaminase 2 by a Liver X Receptor/Retinoic Acid Receptor α Pathway Increases the Clearance of Apoptotic Cells by Human Macrophages

2009

Rationale: Liver X receptors (LXRs) are oxysterol-activated nuclear receptors that are involved in the control of cholesterol homeostasis and inflammatory response. Human monocytes and macrophages express high levels of these receptors and are appropriate cells to study the response to LXR agonists. Objective: The purpose of this study was to identify new LXR targets in human primary monocytes and macrophages and the consequences of their activation. Methods and Results: We show that LXR agonists significantly increase the mRNA and protein levels of the retinoic acid receptor (RAR)α in primary monocytes and macrophages. LXR agonists promote RARα gene transcription through binding to a spec…

Agonistmedicine.medical_specialtyReceptors Retinoic AcidPhysiologymedicine.drug_classResponse elementReceptors Cytoplasmic and NuclearApoptosisBiologyCell LinePhagocytosisGTP-Binding ProteinsInternal medicinemedicineHumansMacrophageProtein Glutamine gamma Glutamyltransferase 2ReceptorLiver X receptorLiver X ReceptorsTransglutaminasesMacrophagesRetinoic Acid Receptor alphaMacrophage ActivationAtherosclerosisOrphan Nuclear ReceptorsCell biologyDNA-Binding ProteinsRetinoic acid receptorEndocrinologyNuclear receptorRetinoic acid receptor alphaEnzyme InductionCardiology and Cardiovascular MedicineCirculation Research
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