0000000000179784

AUTHOR

Paul F. Sauter

showing 7 related works from this author

Synthesis and Evaluation of Novel Ring‐Strained Noncanonical Amino Acids for Residue‐Specific Bioorthogonal Reactions in Living Cells

2021

Abstract Bioorthogonal reactions are ideally suited to selectively modify proteins in complex environments, even in vivo. Kinetics and product stability of these reactions are crucial parameters to evaluate their usefulness for specific applications. Strain promoted inverse electron demand Diels–Alder cycloadditions (SPIEDAC) between tetrazines and strained alkenes or alkynes are particularly popular, as they allow ultrafast labeling inside cells. In combination with genetic code expansion (GCE)‐a method that allows to incorporate noncanonical amino acids (ncAAs) site‐specifically into proteins in vivo. These reactions enable residue‐specific fluorophore attachment to proteins in living mam…

FluorophoreKinetics010402 general chemistry01 natural sciencesCatalysischemistry.chemical_compoundIn vivoChemical BiologyAnimalsAmino AcidsFluorescent Dyeschemistry.chemical_classificationCycloaddition ReactionFull Paper010405 organic chemistryChemistryOrganic ChemistryProteinsprotein engineeringGeneral ChemistryProtein engineeringFull PapersGenetic codelive-cell labeling0104 chemical sciencesAmino acidkineticsAlkynesclick chemistryBiophysicsClick chemistryBioorthogonal chemistryunnatural amino acidsChemistry – A European Journal
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Synthesis of Azido-Glycans for Chemical Glycomodification of Proteins

2018

chemistry.chemical_classificationGlycanGlycosylationbiology010405 organic chemistryChemistryStereochemistryOrganic Chemistry010402 general chemistry01 natural sciences0104 chemical scienceschemistry.chemical_compoundbiology.proteinPhysical and Theoretical ChemistryGlycoproteinEuropean Journal of Organic Chemistry
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CCDC 1565153: Experimental Crystal Structure Determination

2018

Related Article: Mirella Wawryszyn, Paul F. Sauter, Martin Nieger, Martin R.Koos, Christine Koehler, Burkhard Luy, Edward A. Lemke, Stefan Bräse|2018|Eur.J.Org.Chem.|2018|4296|doi:10.1002/ejoc.201800602

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters8-(benzyloxy)-2-(4-methoxyphenyl)-6-[(4-methylphenyl)sulfanyl]hexahydro-2H-pyrano[32-d][13]dioxin-7-yl chloroacetateExperimental 3D Coordinates
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CCDC 1565150: Experimental Crystal Structure Determination

2018

Related Article: Mirella Wawryszyn, Paul F. Sauter, Martin Nieger, Martin R.Koos, Christine Koehler, Burkhard Luy, Edward A. Lemke, Stefan Bräse|2018|Eur.J.Org.Chem.|2018|4296|doi:10.1002/ejoc.201800602

Space GroupCrystallography(1R2R3R4R5R)-2-[(acetyloxy)methyl]-6-azido-5-(13-dioxo-13-dihydro-2H-isoindol-2-yl)oxane-34-diyl diacetateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1565151: Experimental Crystal Structure Determination

2018

Related Article: Mirella Wawryszyn, Paul F. Sauter, Martin Nieger, Martin R.Koos, Christine Koehler, Burkhard Luy, Edward A. Lemke, Stefan Bräse|2018|Eur.J.Org.Chem.|2018|4296|doi:10.1002/ejoc.201800602

Space GroupCrystallography(2S3R4R5S6R)-3-(13-dioxoisoindolin-2-yl)-2-(ethylthio)-6-(hydroxymethyl)-5-((4-methoxybenzyl)oxy)tetrahydro-2H-pyran-4-yl acetateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1565154: Experimental Crystal Structure Determination

2018

Related Article: Mirella Wawryszyn, Paul F. Sauter, Martin Nieger, Martin R.Koos, Christine Koehler, Burkhard Luy, Edward A. Lemke, Stefan Bräse|2018|Eur.J.Org.Chem.|2018|4296|doi:10.1002/ejoc.201800602

(2S3S4S5S6S)-45-bis(benzyloxy)-6-[(benzyloxy)methyl]-2-{[t-butyl(diphenyl)silyl]oxy}oxan-3-yl acetateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1565152: Experimental Crystal Structure Determination

2018

Related Article: Mirella Wawryszyn, Paul F. Sauter, Martin Nieger, Martin R.Koos, Christine Koehler, Burkhard Luy, Edward A. Lemke, Stefan Bräse|2018|Eur.J.Org.Chem.|2018|4296|doi:10.1002/ejoc.201800602

Space GroupCrystallographyCrystal SystemCrystal Structure{4-(acetyloxy)-5-(13-dioxo-13-dihydro-2H-isoindol-2-yl)-6-(ethylsulfanyl)-3-[(4-methoxyphenyl)methoxy]oxan-2-yl}methyl acetateCell ParametersExperimental 3D Coordinates
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