0000000000182193

AUTHOR

Bernhard Kadenbach

showing 3 related works from this author

Mutations of mitochondrial DNA and human death.

1990

In the skeletal muscle of patients with mitochondrial myopathies (Kearns-Sayre syndrome and chronic progressive external ophthalmoplegia) and in the heart and skeletal muscle of healthy persons cells lacking cytochrome c oxidase are found. The respiratory-defective cells have the following features in common: onset of the defect at juvenile or adult age; progressive character of the defect with increasing age; and focal pattern of respiratory-deficient cells (fibers). A statistic mutation of mtDNA in affected cells is suggested to cause the defect of mitochondrial function. It is postulated that the continuous accumulation of respiratory-deficient cells, mainly in the human heart with incre…

Mitochondrial DNAmedicine.medical_specialtyCytochrome-c Oxidase DeficiencyMitochondrionBiologyHuman mitochondrial geneticsDNA MitochondrialMitochondria HeartKearns–Sayre syndromeElectron Transport Complex IVMitochondrial myopathyMuscular DiseasesReference ValuesInternal medicinemedicineAnimalsHumansEcology Evolution Behavior and SystematicsGeneticsMammalsHomoplasmySkeletal muscleGeneral Medicinemedicine.diseaseMitochondria MuscleDeathEndocrinologymedicine.anatomical_structureMutationChronic progressive external ophthalmoplegiaDie Naturwissenschaften
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Book Review: Cytochromes C. Evolutionary, Structural and Physicochemical Aspects. (Springer Series in Molecular Biology). By G. R. Moore And G. W. Pe…

1992

Series (mathematics)Evolutionary biologyPhilosophyGeneral MedicineGeneral ChemistryCatalysisAngewandte Chemie International Edition in English
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Cytochromes c. Evolutionary, Structural, and Physicochemical Aspects. (Reihe: Springer Series in Molecular Biology.) VonG. R. Moore undG. W. Pettigre…

1993

Series (mathematics)Polymer scienceChemistryGeneral MedicineAngewandte Chemie
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