0000000000183217
AUTHOR
Maurizio Di Liberto
showing 2 related works from this author
THE RESISTANCE TO FATIGUE OF DRY ASPHALT RUBBER CONCRETE FOR SUB-BALLAST LAYER
2015
The more and more frequent use of recycled materials within the road and railway infrastructures is now an irreversible trend. In this area the use of Dry Asphalt Rubber Concrete (DARC) in sub-ballast layer seems to be a suitable technique to reach high mechanical and environmental performance even if such material should be analyzed over a long time horizon. This paper presents the results of experimental research focused on the resistance to fatigue of Dry Asphalt Rubber Concrete in sub-ballast layers; the survey has been carried out using four-point bending test (4pbt) on mixture samples with different rubber contents. The results of fatigue in DARC have been compared with the performanc…
Phase 1/2 study of cyclin-dependent kinase (CDK)4/6 inhibitor palbociclib (PD-0332991) with bortezomib and dexamethasone in relapsed/refractory multi…
2015
This phase 1/2 study was the first to evaluate the safety and efficacy of the cyclin-dependent kinase (CDK) 4/6-specific inhibitor palbociclib (PD-0332991) in sequential combination with bortezomib and dexamethasone in relapsed/refractory multiple myeloma. The recommended phase 2 dose was palbociclib 100 mg orally once daily on days 1-12 of a 21-day cycle with bortezomib 1.0 mg/m2 (intravenous) and dexamethasone 20 mg (orally 30 min pre-bortezomib dosing) on days 8 and 11 (early G1 arrest) and days 15 and 18 (cell cycle resumed). Dose-limiting toxicities were primarily cytopenias; most other treatment-related adverse events were grade≤3. At a bortezomib dose lower than that in other combina…