0000000000183417
AUTHOR
Amparo Soler Domingo
La conformación del cooperativismo en Brasil: tendencias y desafíos en el Siglo XXI
The paper deals with the subject of cooperativism focusing on a view of the co-operative system in Brazil, as well as the process of formation and consolidation of the models and the influences of the different aspects of co-operative thought. We then present an analysis of the process of economic modernisation and the transformations in the co-operative system in the 70s to 90s decades, and lastly, we analyse the current tendencies and challenges for cooperativism in Brazil.
Concentración y competencia en la industria turística. Una perspectiva europea
Esta Tesis presenta un estudio de la concentración y competencia a través de un enfoque multidisciplinar. El trabajo en el capítulo primero establece el marco teórico económico - anclado en la Economía Industrial y el segundo el jurídico a través de la práctica decisional de la Comisión europea, cuya regulación está contenida esencialmente en el Reglamento núm. 4064/89 del Consejo sobre el control de las concentraciones empresariales de dimensión comunitaria.Los capítulos tercero y cuarto realizan un análisis de la concentración y competencia aplicado a cada uno de los subsectores de la industria turística. El resultado de este análisis sectorial evidencia los rasgos propios de la competenc…
A phase I pharmacokinetic and pharmacodynamic study of dalotuzumab (MK-0646), an anti-insulin-like growth factor-1 receptor monoclonal antibody, in patients with advanced solid tumors.
Abstract Purpose: Insulin-like growth factor-1 receptor (IGF-1R) mediates cellular processes in cancer and has been proposed as a therapeutic target. Dalotuzumab (MK-0646) is a humanized IgG1 monoclonal antibody that binds to IGF-1R preventing receptor activation. This study was designed to evaluate the safety and tolerability of dalotuzumab, determine the pharmacokinetic (PK) and pharmacodynamic (PD) profiles, and identify a recommended phase II dose. Experimental Design: Patients with tumors expressing IGF-1R protein were allocated to dose-escalating cohorts of three or more patients each and received intravenous dalotuzumab weekly, every 2 or 3 weeks. Plasma was collected for PK analysis…