0000000000184605

AUTHOR

M. Trabucchi

showing 3 related works from this author

Oral and Poster Papers Submitted for Presentation at the 5th Congress of the EUGMS “Geriatric Medicine in a Time of Generational Shift September 3–6,…

2008

GerontologyGeriatrics0303 health sciencesmedicine.medical_specialtyNutrition and Dietetics030309 nutrition & dieteticsGeriatrics gerontologybusiness.industrymedia_common.quotation_subjectAlternative medicineMedicine (miscellaneous)03 medical and health sciencesPresentation0302 clinical medicinemedicine030212 general & internal medicineGeriatrics and GerontologybusinessQuality of Life Researchmedia_commonThe Journal of Nutrition Health and Aging
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Italian consensus recommendations for a biomarker‐based aetiological diagnosis in mild cognitive impairment patients

2019

Background and purpose: Biomarkers support the aetiological diagnosis of neurocognitive disorders in vivo. Incomplete evidence is available to drive clinical decisions; available diagnostic algorithms are generic and not very helpful in clinical practice. The aim was to develop a biomarker-based diagnostic algorithm for mild cognitive impairment patients, leveraging on knowledge from recognized national experts. Methods: With a Delphi procedure, experienced clinicians making variable use of biomarkers in clinical practice and representing five Italian scientific societies (neurology – Società Italiana di Neurologia per le Demenze; neuroradiology – Associazione Italiana di Neuroradiologia; b…

Pediatricsmedicine.medical_specialtyNeurologyConsensusdiagnosisbiomarker-based diagnosis03 medical and health sciences0302 clinical medicineAlzheimer DiseasemedicineHumansCognitive Dysfunction030212 general & internal medicineimplementationNeuroradiologybiomarker-based diagnosiconsensus recommendationDementia with Lewy bodiesbusiness.industryParkinsonismBrainFrontotemporal lobar degenerationmedicine.diseaseMagnetic Resonance Imagingdiagnostic algorithmMCIdiagnosiconsensus recommendationsNeurologyItalymultiple biomarkersPositron-Emission TomographyEtiologyBiomarker (medicine)biomarkerNeurology (clinical)businessNeurocognitiveAlzheimer’s disease030217 neurology & neurosurgeryBiomarkersAlzheimer’s disease; biomarker; biomarker-based diagnosis; consensus recommendations; diagnosis; diagnostic algorithm; implementation; MCI; multiple biomarkers
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Amyloid precursor protein in platelets: A peripheral marker for the diagnosis of sporadic AD

2001

BACKGROUND: An altered pattern of amyloid precursor protein (APP) forms consisting in a reduced ratio between the upper (130 kDa) and the lower (106 to 110 kDa) immunoreactivity bands has been described in platelets of patients with AD. OBJECTIVE: To evaluate the sensitivity and the specificity of platelet APP forms' ratio (APPr) as a marker for AD. METHODS: Eighty-five patients with probable AD and 95 control subjects (CON), including healthy individuals and neurologic patients, entered the study. Platelet APPr was evaluated by means of Western Blot analysis and immunostaining in the whole platelet homogenate, and calculated by the ratio between the optical density (OD) of the upper (130 k…

Blood PlateletsMalePathologymedicine.medical_specialtyBlood cellCentral nervous system diseaseAmyloid beta-Protein PrecursorDegenerative diseaseWestern blotAlzheimer DiseasemedicineAmyloid precursor proteinHumansPlateletAgedPsychiatric Status Rating Scalesmedicine.diagnostic_testbiologybusiness.industryMiddle Agedmedicine.diseaseAbnormalities in the pattern of platelet amyloid precursor protein forms in patients with mild cognitive impairment and Alzheimer diseasemedicine.anatomical_structureAmyloid precursor proteinbiology.proteinFemaleSettore MED/26 - NeurologiaNeurology (clinical)Alzheimer's diseasebusinessImmunostainingBiomarkers
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