Author: Lena Steinhoff

0000000000185819

AUTHOR

Lena Steinhoff

showing 3 related works from this author

Number of nitrate groups determines reactivity and potency of organic nitrates: a proof of concept study in ALDH-2−/− mice

2007

Background and purpose: Mitochondrial aldehyde dehydrogenase (ALDH-2) has been shown to provide a pathway for bioactivation of organic nitrates and to be prone to desensitization in response to highly potent, but not to less potent, nitrates. We therefore sought to support the hypothesis that bioactivation by ALDH-2 critically depends on the number of nitrate groups within the nitrovasodilator. Experimental approach: Nitrates with one (PEMN), two (PEDN; GDN), three (PETriN; glyceryl trinitrate, GTN) and four (pentaerithrityl tetranitrate, PETN) nitrate groups were investigated. Vasodilatory potency was measured in isometric tension studies using isolated aortic segments of wild type (WT) an…

Pharmacologychemistry.chemical_classificationbiologyAldehyde dehydrogenasePentaerythritol tetranitrateDehydrogenaseNitric oxidechemistry.chemical_compoundEnzymeBiochemistrychemistrymedicinebiology.proteinStructure–activity relationshipPotencyNitrovasodilatormedicine.drugBritish Journal of Pharmacology

researchProduct

Normalization of endothelial dysfunction and vascular oxidative stress by chronic atorvastatin treatment in a rat model of streptozotocin-induced dia…

2006

PharmacologyNormalization (statistics)medicine.medical_specialtyPhysiologybusiness.industryAtorvastatinRat modelStreptozotocinmedicine.disease_causemedicine.diseaseDiabetes mellitus type iEndocrinologyInternal medicinemedicineMolecular MedicineEndothelial dysfunctionbusinessOxidative stressmedicine.drugVascular Pharmacology

researchProduct

the role of mitochondrial aldehyde dehydrognase (ALDH-2) for bioactivation of organic nitrates: “Proof of concept” through investigations in ALDH-2 k…

2006

Pharmacologychemistry.chemical_classificationchemistrybiologyBiochemistryPhysiologyStereochemistryKnockout mousebiology.proteinMolecular MedicineAldehyde dehydrogenaseAldehydeOrganic nitratesVascular Pharmacology

researchProduct

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