0000000000186004
AUTHOR
David L. Bigam
28 Milrinone is Preferred to Levosimendan for Mesenteric Perfusion in Hypoxia-Reoxygenated Newborn Piglets on Dopamine
28 Milrinone is Preferred to Levosimendan for Mesenteric Perfusion in Hypoxia-Reoxygenated Newborn Piglets on Dopamine
Milrinone is preferred to levosimendan for mesenteric perfusion in hypoxia-reoxygenated newborn piglets treated with dopamine
INTRODUCTION There is little information regarding the comparative hemodynamic effects of adding milrinone or levosimendan to dopamine infusion in hypoxia-reoxygenated (H-R) newborns. RESULTS Severely hypoxic piglets had cardiogenic shock with depressed cardiac index (CI) and mean arterial pressure (MAP). The hemodynamics deteriorated gradually after initial recovery upon reoxygenation. Heart rate and CI improved with milrinone (D+M) and levosimendan (D+L) administration (P < 0.05 vs. control). Both regimens improved carotid arterial flow and carotid vascular resistance; D+M additionally improved superior mesentric arterial flow (all P < 0.05 vs. control). No effect was found on renal arter…