Rational Design of Copper(II)-Uracil Nanoprocessed Coordination Polymers to Improve Their Cytotoxic Activity in Biological Media
This work is focused on the rational structural design of two isostructural Cu(II) nano-coordination polymers (NCPs) with uracil-1-acetic acid (UAcOH) (CP1n) and 5-fluorouracil-1-acetic acid (CP2n). Suitable single crystals for ꭕ-ray diffraction studies of CP1 and CP2 were prepared under hydrothermal conditions, enabling their structural determination as 1D-CP ladder-like polymeric structures. The control of the synthetic parameters allows their processability into water colloids based on nanoplates (CP1n and CP2n). These NCPs are stable in water at physiological pHs for long periods. However, interestingly, CP1n is chemically altered in culture media. These transformations provoke the part…
CCDC 2064123: Experimental Crystal Structure Determination
Related Article: Verónica G. Vegas, Ana Latorre, María Luisa Marcos, Carlos J. Gómez-García, Óscar Castillo, Félix Zamora, Jacobo Gómez, José Martínez-Costas, Miguel Vázquez López, Álvaro Somoza, Pilar Amo-Ochoa|2021|ACS Applied Materials and Interfaces|13|31|doi:10.1021/acsami.1c11612
CCDC 2064122: Experimental Crystal Structure Determination
Related Article: Verónica G. Vegas, Ana Latorre, María Luisa Marcos, Carlos J. Gómez-García, Óscar Castillo, Félix Zamora, Jacobo Gómez, José Martínez-Costas, Miguel Vázquez López, Álvaro Somoza, Pilar Amo-Ochoa|2021|ACS Applied Materials and Interfaces|13|31|doi:10.1021/acsami.1c11612