0000000000187719

AUTHOR

Arno Reich

showing 3 related works from this author

Optimizing endovascular stroke treatment: removing the microcatheter before clot retrieval with stent-retrievers increases aspiration flow

2016

BackgroundFlow control during endovascular stroke treatment with stent-retrievers is crucial for successful revascularization. The standard technique recommended by stent-retriever manufacturers implies obstruction of the respective access catheter by the microcatheter, through which the stent-retriever is delivered. This, in turn, results in reduced aspiration during thrombectomy. In order to maximize aspiration, we fully retract the microcatheter out of the access catheter before thrombectomy—an approach we term the ‘bare wire thrombectomy’ (BWT) technique. We verified the improved throughput with systematic in vitro studies and assessed the clinical effectiveness and safety of this metho…

AdultMalemedicine.medical_specialtyCathetersAdolescentmedicine.medical_treatmentRevascularizationBalloon030218 nuclear medicine & medical imagingYoung Adult03 medical and health sciences0302 clinical medicinemedicineHumansProspective StudiesChildStrokeAgedRetrospective StudiesThrombectomyStent retrieverAged 80 and overbusiness.industryEndovascular ProceduresStentGeneral MedicineMiddle Agedmedicine.diseaseStandard techniqueSurgeryStrokeStroke treatmentCatheterTreatment OutcomeFemaleStentsSurgeryNeurology (clinical)Radiologybusiness030217 neurology & neurosurgeryJournal of NeuroInterventional Surgery
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Safety of endovascular treatment in acute stroke patients taking oral anticoagulants

2017

International journal of stroke 12(4), 412-415 (2017). doi:10.1177/1747493016677986

Maletherapeutic use [Anticoagulants]medicine.medical_specialtyMedizinAdministration Oral030204 cardiovascular system & hematologyBrain IschemiaBrain ischemia03 medical and health sciences0302 clinical medicineetiology [Intracranial Hemorrhages]Modified Rankin ScaleInterquartile rangeAntithromboticmedicineHumansThrombolytic Therapyddc:610Prospective StudiesRegistriesadverse effects [Anticoagulants]Prospective cohort studyStrokeAgedAged 80 and overbusiness.industryConfoundingAnticoagulantsmethods [Thrombolytic Therapy]complications [Brain Ischemia]Middle Agedmedicine.diseasedrug therapy [Stroke]Surgerysurgery [Stroke]StrokeTreatment Outcomeadministration & dosage [Anticoagulants]Neurologydrug therapy [Brain Ischemia]FemaleObservational studydrug therapy [Intracranial Hemorrhages]businessIntracranial Hemorrhages030217 neurology & neurosurgery
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Faim2 contributes to neuroprotection by erythropoietin in transient brain ischemia.

2018

Delayed cell death in the penumbra region of acute ischemic stroke occurs through apoptotic mechanisms, making it amenable to therapeutic interventions. Fas/CD95 mediates apoptotic cell death in response to external stimuli. In mature neurons, Fas/CD95 signaling is modulated by Fas-apoptotic inhibitory molecule 2 (Faim2), which reduces cell death in animal models of stroke, meningitis, and Parkinson disease. Erythropoietin (EPO) has been studied as a therapeutic strategy in ischemic stroke. Erythropoietin stimulates the phosphatidylinositol-3 kinase/Akt (PI3K/Akt) pathway, which regulates Faim2 expression. Therefore, up-regulation of Faim2 may contribute to neuroprotection by EPO. Male Faim…

Male0301 basic medicinemetabolism [Apoptosis Regulatory Proteins]FAIM2 protein humanlifeguard protein mouseIschemiaNerve Tissue Proteinspathology [Ischemic Attack Transient]physiology [Neuroprotection]PharmacologyBiochemistryNeuroprotectionmetabolism [Erythropoietin]metabolism [Ischemic Attack Transient]Brain ischemiaMice03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicinemedicineAnimalsHumansddc:610ErythropoietinStrokeProtein kinase BPI3K/AKT/mTOR pathwayAgedpharmacology [Erythropoietin]Mice Knockoutmetabolism [Nerve Tissue Proteins]business.industryPenumbraMembrane ProteinsMiddle Agedmedicine.diseaseNeuroprotection030104 developmental biologyIschemic Attack TransientErythropoietinphysiopathology [Ischemic Attack Transient]FemaleDose-dependency ; Erythropoietin ; Fas-apoptotic Inhibitory Molecule 2 ; Ischemia-reperfusion ; Neuroprotection ; StrokeApoptosis Regulatory Proteinsbusinessmetabolism [Membrane Proteins]030217 neurology & neurosurgerymedicine.drug
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