0000000000194142
AUTHOR
Federico M. Giorgi
Measurement of the cross section of high transverse momentumZ→bb¯production in proton–proton collisions ats=8 TeVwith the ATLAS detector
This Letter reports the observation of a high transverse momentum Z -> b (b) over bar signal in proton-proton collisions at root s = 8TeVand the measurement of its production cross section. The data analysed were collected in 2012 with the ATLAS detector at the LHC and correspond to an integrated luminosity of 19.5 fb(-1). The Z -> b (b) over bar decay is reconstructed from a pair of b-tagged jets, clustered with the anti- k(t) jet algorithm with R = 0.4, that have low angular separation and form a dijet with p(T) > 200 GeV. The signal yield is extracted from a fit to the dijet invariant mass distribution, with the dominant, multi-jet background mass shape estimated by employing a fully dat…
A g316a polymorphism in the ornithine decarboxylase gene promoter modulates mycn‐driven childhood neuroblastoma
Simple Summary Neuroblastoma is a devasting childhood cancer in which multiple copies (amplification) of the cancer-causing gene MYCN strongly predict poor outcome. Neuroblastomas are reliant on high levels of cellular components called polyamines for their growth and malignant behavior, and the gene regulating polyamine synthesis is called ODC1. ODC1 is often coamplified with MYCN, and in fact is regulated by MYCN, and like MYCN is prognostic of poor outcome. Here we studied a naturally occurring genetic variant or polymorphism that occurs in the ODC1 gene, and used gene editing to demonstrate the functional importance of this variant in terms of ODC1 levels and growth of neuroblastoma cel…