0000000000194884
AUTHOR
J. Esplugues
Reaction of 4-acylaminomethylpyridine N-oxides with phenylbutazone in the presence of acetic anhydride
INTERACTION BETWEEN SODIUM NITRITE AND BETA ADRENERGIC BLOCKERS ON ISOLATED RAT AORTA
A pharmacological study ofAraujia sericifera B. extracts in rodents
The present study analyses the pharmacological activity in in vitro and in vivo models of different extracts obtained from Araujia sericifera. The hexane extract of fruits lacked toxicity, but exhibited an analgesic effect in models of chemical and thermal stimulation. Such an extract was the only one which exhibited antiinflammatory actions. The intrinsic effect on arterial blood pressure was biphasic: at low doses it significantly increased blood pressure, whereas at high doses it exerted the opposite effect. On isolated organs it produced a marked decrease in the maximum effect of histamine and acetylcholine. The dichloromethanol extract of fruits decreased arterial pressure and the maxi…