Hierarchical modeling for rare event detection and cell subset alignment across flow cytometry samples.
Flow cytometry is the prototypical assay for multi-parameter single cell analysis, and is essential in vaccine and biomarker research for the enumeration of antigen-specific lymphocytes that are often found in extremely low frequencies (0.1% or less). Standard analysis of flow cytometry data relies on visual identification of cell subsets by experts, a process that is subjective and often difficult to reproduce. An alternative and more objective approach is the use of statistical models to identify cell subsets of interest in an automated fashion. Two specific challenges for automated analysis are to detect extremely low frequency event subsets without biasing the estimate by pre-processing…
Aberrant brain functional networks in type 2 diabetes mellitus: A graph theoretical and support-vector machine approach
ObjectiveType 2 diabetes mellitus (T2DM) is a high risk of cognitive decline and dementia, but the underlying mechanisms are not yet clearly understood. This study aimed to explore the functional connectivity (FC) and topological properties among whole brain networks and correlations with impaired cognition and distinguish T2DM from healthy controls (HC) to identify potential biomarkers for cognition abnormalities.MethodsA total of 80 T2DM and 55 well-matched HC were recruited in this study. Subjects’ clinical data, neuropsychological tests and resting-state functional magnetic resonance imaging data were acquired. Whole-brain network FC were mapped, the topological characteristics were ana…
The two-loop supersymmetric corrections to lepton anomalous magnetic and electric dipole moments
Using the effective Lagrangian method, we analyze the electroweak corrections to the anomalous dipole moments of lepton from some special two-loop topological diagrams which are composed of neutralino (chargino) - slepton (sneutrino) in the minimal supersymmetric extension of the standard model (MSSM). Considering the translational invariance of the inner loop momenta and the electromagnetic gauge invariance, we get all dimension 6 operators and derive their coefficients. After applying equations of motion to the external leptons, the anomalous dipole moments of lepton are obtained. The numerical results imply that there is a parameter space where the two-loop supersymmetric corrections to …
Permanent Genetic Resources added to Molecular Ecology Resources Database 1 October 2009–30 November 2009.
5 pages; International audience; This article documents the addition of 411 microsatellite marker loci and 15 pairs of Single Nucleotide Polymorphism (SNP) sequencing primers to the Molecular Ecology Resources Database. Loci were developed for the following species: Acanthopagrus schlegeli, Anopheles lesteri, Aspergillus clavatus, Aspergillus flavus, Aspergillus fumigatus, Aspergillus oryzae, Aspergillus terreus, Branchiostoma japonicum, Branchiostoma belcheri, Colias behrii, Coryphopterus personatus, Cynogolssus semilaevis, Cynoglossus semilaevis, Dendrobium officinale, Dendrobium officinale, Dysoxylum malabaricum, Metrioptera roeselii, Myrmeciza exsul, Ochotona thibetana, Neosartorya fisc…