0000000000198955

AUTHOR

Lin Lin

0000-0002-7464-1172

showing 4 related works from this author

Hierarchical modeling for rare event detection and cell subset alignment across flow cytometry samples.

2013

Flow cytometry is the prototypical assay for multi-parameter single cell analysis, and is essential in vaccine and biomarker research for the enumeration of antigen-specific lymphocytes that are often found in extremely low frequencies (0.1% or less). Standard analysis of flow cytometry data relies on visual identification of cell subsets by experts, a process that is subjective and often difficult to reproduce. An alternative and more objective approach is the use of statistical models to identify cell subsets of interest in an automated fashion. Two specific challenges for automated analysis are to detect extremely low frequency event subsets without biasing the estimate by pre-processing…

Computer scienceAdaptive Immunitycomputer.software_genre0302 clinical medicineSingle-cell analysisEnumerationBiology (General)Immune ResponseEvent (probability theory)0303 health sciencesEcologymedicine.diagnostic_testT CellsStatisticsFlow Cytometry3. Good healthComputational Theory and MathematicsData modelModeling and SimulationMedicineData miningImmunotherapyResearch ArticleTumor ImmunologyQH301-705.5Immune CellsImmunologyContext (language use)BiostatisticsModels BiologicalFlow cytometry03 medical and health sciencesCellular and Molecular NeuroscienceGeneticsmedicineHumansSensitivity (control systems)Statistical MethodsImmunoassaysMolecular BiologyBiologyEcology Evolution Behavior and Systematics030304 developmental biologybusiness.industryImmunityReproducibility of ResultsPattern recognitionStatistical modelImmunologic SubspecialtiesLymphocyte SubsetsImmunologic TechniquesClinical ImmunologyArtificial intelligencebusinesscomputerMathematics030215 immunologyPLoS computational biology
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Aberrant brain functional networks in type 2 diabetes mellitus: A graph theoretical and support-vector machine approach

2022

ObjectiveType 2 diabetes mellitus (T2DM) is a high risk of cognitive decline and dementia, but the underlying mechanisms are not yet clearly understood. This study aimed to explore the functional connectivity (FC) and topological properties among whole brain networks and correlations with impaired cognition and distinguish T2DM from healthy controls (HC) to identify potential biomarkers for cognition abnormalities.MethodsA total of 80 T2DM and 55 well-matched HC were recruited in this study. Subjects’ clinical data, neuropsychological tests and resting-state functional magnetic resonance imaging data were acquired. Whole-brain network FC were mapped, the topological characteristics were ana…

kognitiiviset taidottype 2 diabetes mellitusmagneettikuvaushermoverkot (biologia)resting-state MRIbiomarkkeritBehavioral NeurosciencePsychiatry and Mental healthkoneoppiminenaivokuoriNeuropsychology and Physiological PsychologyNeurologyauditory cortexsupport vector machinetopological propertiesaikuistyypin diabetescognitive functionBiological PsychiatryFrontiers in Human Neuroscience
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The two-loop supersymmetric corrections to lepton anomalous magnetic and electric dipole moments

2006

Using the effective Lagrangian method, we analyze the electroweak corrections to the anomalous dipole moments of lepton from some special two-loop topological diagrams which are composed of neutralino (chargino) - slepton (sneutrino) in the minimal supersymmetric extension of the standard model (MSSM). Considering the translational invariance of the inner loop momenta and the electromagnetic gauge invariance, we get all dimension 6 operators and derive their coefficients. After applying equations of motion to the external leptons, the anomalous dipole moments of lepton are obtained. The numerical results imply that there is a parameter space where the two-loop supersymmetric corrections to …

PhysicsNuclear and High Energy PhysicsParticle physicsMuon010308 nuclear & particles physicsElectroweak interactionHigh Energy Physics::PhenomenologyFOS: Physical sciencesSupersymmetry01 natural sciences3. Good healthHigh Energy Physics - PhenomenologyStandard Model (mathematical formulation)DipoleHigh Energy Physics - Phenomenology (hep-ph)Quantum electrodynamics0103 physical sciencesCP violationHigh Energy Physics::ExperimentGauge theory010306 general physicsLepton
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Permanent Genetic Resources added to Molecular Ecology Resources Database 1 October 2009–30 November 2009.

2010

5 pages; International audience; This article documents the addition of 411 microsatellite marker loci and 15 pairs of Single Nucleotide Polymorphism (SNP) sequencing primers to the Molecular Ecology Resources Database. Loci were developed for the following species: Acanthopagrus schlegeli, Anopheles lesteri, Aspergillus clavatus, Aspergillus flavus, Aspergillus fumigatus, Aspergillus oryzae, Aspergillus terreus, Branchiostoma japonicum, Branchiostoma belcheri, Colias behrii, Coryphopterus personatus, Cynogolssus semilaevis, Cynoglossus semilaevis, Dendrobium officinale, Dendrobium officinale, Dysoxylum malabaricum, Metrioptera roeselii, Myrmeciza exsul, Ochotona thibetana, Neosartorya fisc…

0106 biological sciencesColias interiorcomputer.software_genre010603 evolutionary biology01 natural sciences03 medical and health sciencesfoodBotanyGeneticsEcology Evolution Behavior and Systematics030304 developmental biology0303 health sciences[SDV.GEN]Life Sciences [q-bio]/GeneticsbiologyDatabaseSalvia officinalisbiology.organism_classificationfood.foodDendrobium devonianumDendrobium loddigesiiNothofagus obliquaSula nebouxiiColias eurytheme[ SDV.GEN ] Life Sciences [q-bio]/GeneticsAspergillus clavatuscomputerBiotechnology
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