0000000000199537
AUTHOR
Ilaria Mancini
Logarithmic Equal-Letter Runs for BWT of Purely Morphic Words
In this paper we study the number r(bwt) of equal-letter runs produced by the Burrows-Wheeler transform (BWT) when it is applied to purely morphic finite words, which are words generated by iterating prolongable morphisms. Such a parameter r(bwt) is very significant since it provides a measure of the performances of the BWT, in terms of both compressibility and indexing. In particular, we prove that, when BWT is applied to whichever purely morphic finite word on a binary alphabet, r(bwt) is O(log n), where n is the length of the word. Moreover, we prove that r(bwt) is Theta(log n) for the binary words generated by a large class of prolongable binary morphisms. These bounds are proved by pro…
Open ADAMTS13, induced by antibodies, is a biomarker for subclinical immune-mediated thrombotic thrombocytopenic purpura
Recently, we showed that ADAMTS13 circulates in an open conformation during the acute phase of immune-mediated thrombotic thrombocytopenic purpura (iTTP). Although the cause of this conformational change remains elusive, ADAMTS13 is primarily closed in iTTP patients in remission with ADAMTS13 activity >50% and undetectable anti-ADAMTS13 autoantibodies, as well as after rituximab treatment, suggesting a role for anti-ADAMTS13 autoantibodies. Therefore, immunoglobulin G from 18 acute iTTP patients was purified and added to closed ADAMTS13 in healthy donor plasma. This resulted in open ADAMTS13 in 14 of 18 (78%) samples, proving that anti-ADAMTS13 autoantibodies can induce an open ADAMTS13 con…