0000000000199755
AUTHOR
S Davì
Musculoskeletal manifestations of childhood cancer and differential diagnosis with juvenile idiopathic arthritis (ONCOREUM): a multicentre, cross-sectional study
Summary Background Presenting symptoms of childhood cancers might mimic those of rheumatic diseases. However, the evidence available to guide differential diagnosis remains scarce. Preventing wrong or delayed diagnosis is therefore important to avoid incorrect administration of glucocorticoid or immunosuppressive therapy and worsening of prognosis. As such, we aimed to assess the prevalence and characteristics of presenting musculoskeletal manifestations in patients at cancer onset and to identify the factors that differentiate childhood malignancies with arthropathy from juvenile idiopathic arthritis. Methods We did a multicentre, cross-sectional study at 25 paediatric haemato-oncology cen…
Correction of B-scan distortion for optimum ultrasonic imaging of backwalls with complex geometries
Ultrasound undergoes refraction and reflection at interfaces between media of different acoustic refractive indices. The most common ultrasonic method (pulse-echo) monitors the reflected energy to infer the presence of flaws, whereas the lower amplitude of refracted signals is ignored. When the reflector is orientated normally with respect to the ultrasonic beam, the received echo signal shows the maximum amplitude. The pulse-echo method also relies on monitoring the amplitude of the backwall echo to identify or confirm the presence of defects. This works well for parts with constant thickness and with planar backwalls. Unfortunately, parts with complex backwalls are common to many industri…