0000000000201181

AUTHOR

Frank P. Luyten

showing 2 related works from this author

Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium

2011

Objective: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods: Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating various hip OA definitions in one large population based cohort (the Rotterdam Study I (RSI)) and testing those for association with gender, age and body mass index using one-way ANOVA. For ROA, we standardized the hip-, knee- and hand ROA definitions and calculated prevalence's of RO…

Malenivelrikkomedicine.medical_specialtygenetiikkaBiomedical EngineeringMEDLINEdiagnostiset kriteeritOsteoarthritisbehavioral disciplines and activitiesArticleCohort Studies03 medical and health sciencesRotterdam Study0302 clinical medicineRheumatologyInternal medicineTREATOAOsteoarthritismedicinePrevalenceGeneticsHumansOrthopedics and Sports Medicine030304 developmental biologyRheumatology and Autoimmunity2. Zero hunger030203 arthritis & rheumatology0303 health sciencesAnalysis of Varianceperinnöllisyystiedebusiness.industryCase-control studyDefinitionReference Standardsmedicine.diseaseGenetics Osteoarthritis Phenotype Definition TREATOA genome-wide association radiographic hip osteoarthritis bone-mineral density knee osteoarthritis hand osteoarthritis osteoporotic fractures general-population joint involvement risk-factors susceptibilityRheumatology3. Good healthPhenotypeCase-Control Studiesdiagnostic criteriaCohortPhysical therapyFemalebusinessBody mass indexCohort study
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Effects of MRI Contrast Agents on the Stem Cell Phenotype

2010

The ultimate therapy for ischemic stroke is restoration of blood supply in the ischemic region and regeneration of lost neural cells. This might be achieved by transplanting cells that differentiate into vascular or neuronal cell types, or secrete trophic factors that enhance self-renewal, recruitment, long-term survival and functional integration of endogenous stem/progenitor cells. Experimental stroke models have been developed to determine potential beneficial effect of stem/progenitor cell based therapies. To follow the fate of grafted cells in vivo, a number of non-invasive imaging approaches have been developed. Magnetic Resonance Imaging (MRI) is a high resolution, clinically relevan…

MaleCell typePopulationBiomedical EngineeringContrast Medialcsh:MedicineBiology03 medical and health sciencesMice0302 clinical medicineIn vivoCell MovementAnimalsProgenitor celleducationMagnetite NanoparticlesEmbryonic Stem Cells030304 developmental biology0303 health sciencesTransplantationeducation.field_of_studyRegeneration (biology)Multipotent Stem CellsMesenchymal stem celllcsh:RCell DifferentiationDextransMesenchymal Stem CellsCell BiologyFlow CytometryEmbryonic stem cellMagnetic Resonance Imaging3. Good healthCell biologyRatsStrokePhenotypeFemaleStem cell030217 neurology & neurosurgeryCell Transplantation
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