0000000000201609
AUTHOR
Maksym ŻUk
Efficacy of systemic administration of riboflavin on a rabbit model of corneal alkali burn
AbstractChanges in the barrier mechanisms in the eye should determine the rational route for the administration and dosage of each drug in the treatment of traumatic injuries and other pathologies. The aim of this study was to examine the efficacy of intra-arterial delivery of 14C-riboflavin (as an “indicator”) and compare it with intravenous and intramuscular administration in an animal model of chemical eye burn. 14C-riboflavin (14C-I) was administered by intra-arterial (carotid artery), intravenous (femoral vein) and intramuscular (femoral muscle) routes. The total radioactivity was determined over 2 h in the plasma and structures of the rabbit’s eyes using a scintillation counter. The r…
Elimination kinetics of synthetic interferon inducer tilorone in experimental animals
Objective. A comparative investigation was carried out on the kinetics of [3H]-tilorone ([3H]-I) excretion in rats and mice. Materials and method. Kinetics of urinary and biliary excretion of [3H]-I in rats and mice was studied following a single oral and intravenous administration. The excretion mass balance was monitored in the faeces and urine of rats and mice for 5 and 10 days, respectively. Radioactivity was determined in the samples of excreta using a liquid scintillation counter. Results. In rats, [3H]-I were nearly fully (~80%) eliminated with excreta in 5 days, indicating a lack of any significant accumulation of the drug in the body. Faecal excretion of tilorone predominated (69.0…