0000000000202188

AUTHOR

Andy Zedet

showing 2 related works from this author

Negative Impact of Citral on Susceptibility of Pseudomonas aeruginosa to Antibiotics

2021

Essential oils (EOs) or their components are widely used by inhalation or nebulization to fight mild respiratory bacterial infections. However, their interaction with antibiotics is poorly known. In this study we evaluated the effects of citral, the main component of lemongrass oil, on in vitro susceptibility of Pseudomonas aeruginosa to antibiotics. Exposure of strain PA14 to subinhibitory concentrations of citral increased expression of operons encoding the multidrug efflux systems MexEF-OprN and MexXY/OprM, and bacterial resistance to anti-pseudomonal antibiotics including imipenem (twofold), gentamicin (eightfold), tobramycin (eightfold), ciprofloxacin (twofold), and colistin (≥128-fold…

0301 basic medicineMicrobiology (medical)antibiotic resistancemedicine.drug_class[SDV]Life Sciences [q-bio]030106 microbiologyAntibioticsmedicine.disease_causeCitralMicrobiologyMicrobiology03 medical and health scienceschemistry.chemical_compoundtobramycin-citral Schiff baseTobramycinmedicine[CHIM]Chemical Sciencesessential oilscitralOriginal ResearchPseudomonas aeruginosaChemistryAminoglycosidecolistin-citral Schiff baseSciences du Vivant [q-bio]/Microbiologie et Parasitologie[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/BacteriologyeffluxQR1-5023. Good health030104 developmental biology[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/PharmacologyPseudomonas aeruginosaColistin[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/PharmacologyGentamicinEfflux[SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriologymedicine.drugFrontiers in Microbiology
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Cinnamaldehyde Induces Expression of Efflux Pumps and Multidrug Resistance in Pseudomonas aeruginosa

2019

Essential oils or their components are increasingly used to fight bacterial infections. Cinnamaldehyde (CNA), the main constituent of cinnamon bark oil, has demonstrated interesting properties in vitro against various pathogens, including Pseudomonas aeruginosa. In the present study, we investigated the mechanisms and possible therapeutic consequences of P. aeruginosa adaptation to CNA. Exposure of P. aeruginosa PA14 to subinhibitory concentrations of CNA caused a strong albeit transient increase in the expression of operons that encode the efflux systems MexAB-OprM, MexCD-OprJ, MexEF-OprN, and MexXY/OprM. This multipump activation enhanced from 2- to 8-fold the resistance (MIC) of PA14 to …

medicine.drug_classAntibioticsMicrobial Sensitivity Testsmedicine.disease_causeCinnamaldehydeMicrobiology03 medical and health scienceschemistry.chemical_compoundAntibiotic resistanceMechanisms of ResistanceDrug Resistance Multiple BacterialOils VolatilemedicineTobramycin[CHIM]Chemical SciencesPharmacology (medical)AcroleinComputingMilieux_MISCELLANEOUS030304 developmental biologyPharmacology0303 health sciences030306 microbiologyPseudomonas aeruginosaMembrane Transport Proteins[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biologybiochemical phenomena metabolism and nutrition[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciencesAnti-Bacterial Agents3. Good healthCiprofloxacinMultiple drug resistanceInfectious DiseaseschemistryPseudomonas aeruginosaEffluxmedicine.drug
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