0000000000203691
AUTHOR
P D'angelo
LA SEDAZIONE PROCEDURALE IN ONCOEMATOLOGIA PEDIATRICA
Post-chemotherapy physical fitness level on children with diagnosis of leukemia: results of a pilot study
Introduction: Children with diagnosis of leukemia are at risk for developing neuromuscular and musculoskeletal complications such as decreased muscle strength, impaired gross and fine motor performance, decreased energy expenditure, osteonecrosis, and osteoporosis. These secondary complications due to the medical interventions may lead to activity limitations and participation restrictions in daily life experiences. However, few Authors suggest that if children participate in an individualized physical therapy exercise program, these limitations may be prevented or at least reduced. We evaluated the level of physical fitness on children with diagnosis of leukemia (C-LK) during the post-chem…
Comparison of paediatric cancers outcomes between Palermo Province (Sicily) and Southern Europe
Background: Italy has one of the highest paediatric cancer incidence rate in Europe. We compared cancer incidence and survival in children (0-14 years) and adolescents (15-19 years) resident in Palermo Province with statistics derived from Italian and European surveillance systems. Methods: We included all incident cancer cases, malignant tumours and non-malignant neoplasm of central nervous system (benign and uncertain whether malignant or benign), detected in children and adolescents by the Palermo Province Cancer Registry between 2003 and 2012. A joinpoint regression model was applied. Annual Average Percentage Changes were calculated. The Besag–York–Mollie model was used to detect any c…
PEDIATRIC TESTICULAR GERM CELL TUMORS: the ASSOCIAZIONE ITALIANA ONCOLOGIA PEDIATRICA (AIEOP) study
We describe the results of a therapeutic approach with a pediatric BEP regimen (bleomycin, etoposide, cisplatin) from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) study on testicular germ cell tumors (TGCT).
Clinical features and follow-up in patients with 22q11.2 deletion syndrome
Objective To investigate the clinical manifestations at diagnosis and during follow-up in patients with 22q11.2 deletion syndrome to better define the natural history of the disease. Study design A retrospective and prospective multicenter study was conducted with 228 patients in the context of the Italian Network for Primary Immunodeficiencies. Clinical diagnosis was confirmed by cytogenetic or molecular analysis. Results The cohort consisted of 112 males and 116 females; median age at diagnosis was 4 months (range 0 to 36 years 10 months). The diagnosis was made before 2 years of age in 71% of patients, predominantly related to the presence of heart anomalies and neonatal hypocalcemia. In…
STAGE-I GOMADAL GERMS CELL TUMORS (GGCT):OUTCOME AFTER THE SURVEILLANCE STRATEGY AS APPLIED IN THE ASSOCIAZIONE ITALIANA EMATOLOGIA ONCOLOGIA PEDIATRICA (AIEOP) 2004 PROTOCOL
PROGETTO PILOTA PER LO SVOLGIMENTO DELL’ATTIVITA’ MOTORIA IN BAMBINI E ADOLESCENTI CON PREGRESSA NEOPLASIA
L’ATTIVITA’ FISICA NEI BAMBINI CON PREGRESSA NEOPLASIA: PREVENZIONE DEL RISCHIO NEUROMUSCOLARE E MUSCOLO-SCHELETRICO
Comparative Effectiveness of DPP-4 Inhibitors Versus Sulfonylurea for the Treatment of Type 2 Diabetes in Routine Clinical Practice: A Retrospective Multicenter Real-World Study
Introduction DPP-4 inhibitors (DPP4i) and sulfonylureas are popular second-line therapies for type 2 diabetes (T2D), but there is a paucity of real-world studies comparing their effectiveness in routine clinical practice. Methods This was a multicenter retrospective study on diabetes outpatient clinics comparing the effectiveness of DPP4i versus gliclazide extended release. The primary endpoint was change from baseline in HbA1c. Secondary endpoints were changes in fasting plasma glucose, body weight, and systolic blood pressure. Automated software extracted data from the same clinical electronic chart system at all centers. Propensity score matching (PSM) was used to generate comparable coh…
Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial
Background The best treatment option for patients with type 2 diabetes in whom treatment with metformin alone fails to achieve adequate glycaemic control is debated. We aimed to compare the long-term effects of pioglitazone versus sulfonylureas, given in addition to metformin, on cardiovascular events in patients with type 2 diabetes. Methods TOSCA.IT was a multicentre, randomised, pragmatic clinical trial, in which patients aged 50â75 years with type 2 diabetes inadequately controlled with metformin monotherapy (2â3 g per day) were recruited from 57 diabetes clinics in Italy. Patients were randomly assigned (1:1), by permuted blocks randomisation (block size 10), stratified by site and…
ELEMENTO POLIFUNZIONALE DI ARREDO
Il design brevettato rientra nella categoria di arredi per strutture educative destinate a bambini di età compresa tra 1 e 3 anni. L'arredo consta di due elementi indipendenti e componibili, realizzati in cartone riciclato, che possono assumere alternativamente la configurazione di poltrona e scrittoio con seduta.
Leukemic ophthalmopathy: a report of 21 pediatric cases.
A multicentric retrospective study on leukemic ophthalmopathy (LO) is reported. It includes 21 patients, 16 males and 5 females, with acute leukemia (AL) observed in 10 SIOP centers. LO developed in three patients at the time of diagnosis of AL; five patients were in first complete remission (three off therapy); four patients were in second or third remission; and nine were in combined relapse. Most frequent symptoms were blurred vision, photophobia, and ocular pain. Two patients with acute nonlymphoblastic leukemia died before treatment; another underwent bone marrow transplantation; one patient with B-cell acute lymphoblastic leukemia (B-ALL) treated with chemotherapy and radiotherapy die…