The Impact of Copper Ions on Oxidative Stress in Garden Cress Lepidium sativum

Abstract Normal oxygen metabolism is an endogenous source of reactive oxygen species (ROS). The source of ROS are also many environmental factors including heavy metals. In certain concentration range, the presence of ROS is necessary to maintain proper cell function. Thus, cells have many mechanisms, which role is focused on maintaining a constant concentration of ROS. Imbalance between the formation of ROS and action of a protective antioxidant system leads to oxidative stress. This may results with a damage to the structure of proteins, lipids and nucleic acids, which in turn can lead to disturbances in the functioning of the cell and even to the death. The aim of the study was to evalua…

Formalisation and methods of analysis of the fast xenobiotic mass transfer in the body

Modeling dynamics of paroxysmal activity and pharmacokinetics of GABAA receptor ligands during their direct application into their biophase of action

Model-independent method of the analysis of distribution of 1,4-benzodiazepine derivatives possessing psychotropic activity after a single administration in the mice

Elimination kinetics of synthetic interferon inducer tilorone in experimental animals

Objective. A comparative investigation was carried out on the kinetics of [3H]-tilorone ([3H]-I) excretion in rats and mice. Materials and method. Kinetics of urinary and biliary excretion of [3H]-I in rats and mice was studied following a single oral and intravenous administration. The excretion mass balance was monitored in the faeces and urine of rats and mice for 5 and 10 days, respectively. Radioactivity was determined in the samples of excreta using a liquid scintillation counter. Results. In rats, [3H]-I were nearly fully (~80%) eliminated with excreta in 5 days, indicating a lack of any significant accumulation of the drug in the body. Faecal excretion of tilorone predominated (69.0…

Functional Dependence Between Expectancy of People’S Life and Mankind Population During the Time of Demographic Transition / Funkcjonalna Zależność Trwałości Życia Ludzi Od Liczebności Ludzkości Świata W Okresie Przejścia Demograficznego

Abstract In this work is an attempt to mathematically prove the existence of the demographic transition taking into account one of its features, such as extension of human life dependent on the growth of the human population. Determined the functional form of this dependence, and the relationship between the probability of death, life expectancy, and social involving in the states of T (the influence of “traditional” values of concepts) and R (in the range of rules and possibilities of modern civilization).

Elimination kinetics of the novel prodrug cinazepam possessing psychotropic activity in mice.

Abstract The kinetics of excretion of the novel tranquilizer cinazepam (3-hydroxy-7-bromo-5-( ortho -chlorophenyl)-1,2-dihydro-3H-1,4-benzdiazepin-2-one hemisuccinate (I)) in mice after a single administration and different schemes of multiple administration were determined. Mass balance was studied daily in excretions of mice (feces and urine) for 5-10 days. We observed that monoexponen-tial renal excretion of 14 C-cinazepam and its metabolites predominated with all dosage regimens. Cinazepam and its metabolites were almost fully (> 90%) eliminated in urine and feces over the period of study (5-10 days), which means that no significant accumulation of the drug in the body occurred. The kin…

Research on Acute Toxicity and the Behavioral Effects of Methanolic Extract from Psilocybin Mushrooms and Psilocin in Mice

The pharmacological activities and acute toxicity of the psilocin (PC) and dried residues of the crude extracts of psychotropic mushrooms were investigated in mice. The hallucinogenic substances were effectively isolated, by using methanol, from the species of Psilocybe semilanceata and Pholiotina cyanopus, that were collected in the north-east region of Poland. The chemical analysis of these extracts, which was performed by liquid chromatography with mass spectrometry detection (LC-MS), indicated the presence of psilocin and other hallucinogenic substances, including indolealkylamines and their phosphorylated analogues. When the pure psilocin or fungal extracts were used, slight difference…