0000000000205474

AUTHOR

Patricia Rico

showing 2 related works from this author

Boron Ions: Simultaneous Boron Ion‐Channel/Growth Factor Receptor Activation for Enhanced Vascularization (Adv. Biosys. 1/2019)

2019

biologyChemistryVEGF receptorsIntegrinBiomedical Engineeringchemistry.chemical_elementGeneral Biochemistry Genetics and Molecular BiologyIonBiomaterialsFibronectinGrowth factor receptorbiology.proteinBiophysicsBoronIon channelAdvanced Biosystems
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Simultaneous Boron Ion‐Channel/Growth Factor Receptor Activation for Enhanced Vascularization

2018

[EN] Boron ion is essential in metabolism and its concentration is regulated by ion-channel NaBC1. NaBC1 mutations cause corneal dystrophies such as Harboyan syndrome. Here we propose a 3D molecular model for NaBC1 and show that simultaneous stimulation of NaBC1 and vascular growth factor receptors (VEGFR) promote angiogenesis in vitro and in vivo with ultra-low concentrations of VEGF. We show Human Umbilical Vein Endothelial Cells (HUVEC) organization into tubular structures indicative of vascularization potential. Enhanced cell sprouting was found only in the presence of VEGF and boron, effect abrogated after blocking NaBC1. We demonstrate that stimulated NaBC1 promotes angiogenesis via P…

0301 basic medicineIntegrinsVEGF receptorsBiomedical EngineeringEuropean Regional Development FundLibrary scienceBoron ionGeneral Biochemistry Genetics and Molecular BiologyBiomaterials03 medical and health sciencesNaBC10302 clinical medicineGrowth factor receptorPolitical scienceFibronectinbiologyEuropean researchVascularizationChick embryosVEGFEngineering and Physical Sciences030104 developmental biologyResearch councilFISICA APLICADA030220 oncology & carcinogenesisbiology.proteinCam assayAdvanced Biosystems
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