The “mode” of lymphocyte extravasation through HEV of Peyer's patches and its role in normal homing and inflammation

The mode of lymphocyte transendothelial migration in the postcapillary high endothelial venules (HEVs) of Peyer's patches during normal homing and acute inflammation in the guinea pig was studied. It is common opinion that the lymphocyte transendothelial passage from the blood stream into the extravasal lymphoid tissue calls for a multistep process of endothelial and lymphocyte molecules favoring tethering, rolling, activation, arrest and its firm adhesion to the endothelial luminal surface. Ultrastructural serial pictures and the three-dimensional reconstruction of HEVs with lymphocytes during different moments of their transmigration through the endothelial wall enabled us to demonstrate …

On the lymphocyte transendothelial migration at the level of absorbing lymphatic vessel of thymus-dependent lymphoid areas of Peyer's patches

On the absorbent peripheral lymphatic vessel (ALPA) vessel in some experimental toumors