0000000000215229

AUTHOR

Ilaria Radano

showing 3 related works from this author

Beta-blockers are associated with better long-term survival in patients with Takotsubo syndrome

2022

ObjectiveThe advantage of beta-blockers has been postulated in patients with Takotsubo syndrome (TTS) given the pathophysiological role of catecholamines. We hypothesised that beta-blocker treatment after discharge may improve the long-term clinical outcome in this patient population.MethodsThis was an observational, multicentre study including consecutive patients with TTS diagnosis prospectively enrolled in the Takotsubo Italian Network (TIN) register from January 2007 to December 2018. TTS was diagnosed according to the TIN, Heart Failure Association and InterTAK Diagnostic Criteria. The primary study outcome was the occurrence of all-cause death at the longest available follow-up; secon…

MaleOutcome AssessmentAdrenergic beta-AntagonistsShockCardiogenicHealth CareTinTakotsubo CardiomyopathyHypertensionOutcome Assessment Health CareHumansFemaleCardiomyopathiesCardiology and Cardiovascular MedicineCardiomyopathies; Hypertension; Outcome Assessment Health Care; Adrenergic beta-Antagonists; Aged; Female; Humans; Male; Shock Cardiogenic; Tin; Hypertension; Takotsubo CardiomyopathyAgedHeart
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Long-term outcome in patients with Takotsubo syndrome presenting with severely reduced left ventricular ejection fraction

2019

Aim: To evaluate the long-term outcome of patients with Takotsubo syndrome (TTS) and severely reduced left ventricular ejection fraction (LVEF ≤ 35%) at presentation. Methods and results: The study population included 326 patients (mean age 69.5 ± 10.7 years, 28 male) with TTS enrolled in the Takotsubo Italian Network, divided into two groups according to LVEF (≤ 35%, n = 131; > 35%, n = 195), as assessed by transthoracic echocardiography at hospital admission. In-hospital events were recorded in both groups. At long-term follow-up (median 26.5 months, interquartile range 18–33), composite major adverse cardiac events (MACE: cardiac death, acute myocardial infarction, heart failure, and …

medicine.medical_specialtyLeft ventricular ejection fractionCardiomyopathyHeart failure030204 cardiovascular system & hematology03 medical and health sciences0302 clinical medicineInterquartile rangeInternal medicinemedicinecardiovascular diseasesMyocardial infarctionCardiogenic shock; Cardiomyopathy; Heart failure; Left ventricular ejection fraction; Takotsubo syndromeCardiogenic shockEjection fractionbusiness.industryCardiogenic shockHazard ratiomedicine.diseaseConfidence intervalHeart failureCardiologybusinessTakotsubo syndromeCardiology and Cardiovascular MedicineCardiogenic shock; Cardiomyopathy; Heart failure; Left ventricular ejection fraction; Takotsubo syndrome; Cardiology and Cardiovascular MedicineMace
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5037Drug treatment with beta-blockers and long-term outcome in patients with takotsubo syndrome: results from the takotsubo Italian network

2019

Abstract Background Although generally considered a benign disease, Takotsubo syndrome (TTS) has recently been associated to a substantially comparable long-term outcome than acute coronary syndrome (ACS). The use of beta-blockers (BB) has been advocated in these patients for secondary prevention after the index event, considering the presumed role of catecholamine in TTS pathophysiology. However, the effect of BB on long-term outcome remains controversial due to the paucity of data and the lack of evidence from randomized studies. Purpose To investigate the impact of BB therapy on long-term outcome in patients with TTS. Methods The study included all TTS patients enrolled in the Takotsubo …

medicine.medical_specialtyTakotsubo syndromebusiness.industrymedicine.diseaseTerm (time)PharmacotherapyHeart failureInternal medicinemedicineCardiologyIn patientCardiology and Cardiovascular MedicineBeta (finance)businessEuropean Heart Journal
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