0000000000217149

AUTHOR

Howe Robin

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Etestw versus broth microdilution for ceftaroline MIC determination with Staphylococcus aureus: Results from PREMIUM, a European multicentre study

2017

Objectives: To compare the concordance of ceftaroline MIC values by reference broth microdilution (BMD) and Etest (bioMérieux, France) for MSSA and MRSA isolates obtained from PREMIUM (D372SL00001), a European multicentre study. Methods: Ceftaroline MICs were determined by reference BMD and by Etest for 1242 MSSA and MRSA isolates collected between February and May 2012 from adult patients with community-acquired pneumonia or complicated skin and soft tissue infections; tests were performed across six European laboratories. Selected isolates with ceftaroline resistance in broth (MIC >1 mg/L) were retested in three central laboratories to confirm their behaviour. Results: Overall concordance…

Male0301 basic medicineCephalosporinPharmacologiemedicine.disease_causeCommunity-acquired pneumoniaPneumonia StaphylococcalCommunity-Acquired InfectionPharmacology (medical)Pathologie maladies infectieusesAged 80 and overMicrobial Sensitivity TestBroth microdilutionCeftalorine; Staphylococcus aureus; PREMIUM STUDY GROUPCeftalorineMiddle AgedAnti-Bacterial AgentsCommunity-Acquired InfectionsEuropeInfectious DiseasesStaphylococcus aureusStaphylococcus aureuStaphylococcal Skin InfectionsFemaleHumanAdultMicrobiology (medical)medicine.medical_specialtyStaphylococcus aureusAdolescentmedicine.drug_classCephalosporin030106 microbiologyPREMIUM STUDY GROUPMicrobial Sensitivity TestsStaphylococcal Skin InfectionMicrobiologyYoung Adult03 medical and health sciencesInternal medicineAnti-Bacterial AgentmedicineHumansEtestAgedPharmacologyAdult patientsbusiness.industrybiochemical phenomena metabolism and nutritionmedicine.diseasebacterial infections and mycosesMethicillin-resistant Staphylococcus aureusCephalosporinsMethicillin Susceptible Staphylococcus Aureusbusiness
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