0000000000217199

AUTHOR

C. Chatard

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Expression of the multidrug resistance glycoprotein 170 in the peripheral blood lymphocytes of rheumatoid arthritis patients. The percentage of lymph…

1996

International audience; Abstract: The objective was to evaluate the expression of the multidrug resistance P-glycoprotein (P-gp) in peripheral blood lymphocytes (PBL) of patients with rheumatoid arthritis (RA). PBL from 68 RA patients and 44 controls were evaluated. RA patients had a mean disease duration of 10.7 yr, with a mean number of past resistances to DMARDs of 0.82, and were treated with NSAIDs (n = 34), DMARDs (n = 25) and prednisolone (n = 40). Fluorescence flow cytometry was used to assess P-gp membrane expression on PBL. In the RA group, the percentage of PBL expressing P-gp was higher in patients treated with prednisolone than in other patients [mean +/- S.D.: 10.7 +/- 15.8% vs…

Malerheumatoid arthritismedicine.drug_classmedicine.medical_treatmentLymphocytePrednisolone[INFO.INFO-IM] Computer Science [cs]/Medical ImagingDrug resistanceArthritis Rheumatoidresistance03 medical and health sciences0302 clinical medicineRheumatologyImmunopathologyMDRmedicine[INFO.INFO-IM]Computer Science [cs]/Medical ImagingHumansPharmacology (medical)ATP Binding Cassette Transporter Subfamily B Member 1Lymphocytes030304 developmental biologyAgedAutoimmune disease0303 health sciencesChemotherapytreatmentglucocorticoids[ INFO.INFO-IM ] Computer Science [cs]/Medical Imagingbusiness.industryAnti-Inflammatory Agents Non-SteroidaldrugMiddle Agedmedicine.diseaseDrug Resistance Multiple3. Good healthmedicine.anatomical_structure030220 oncology & carcinogenesisRheumatoid arthritisAntirheumatic AgentsImmunologyMultivariate AnalysisPrednisoloneCorticosteroidRegression AnalysisFemalebusinessmedicine.drug
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