0000000000217274

AUTHOR

Johannes Geisinger

showing 2 related works from this author

Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans

2017

Autophagy is a ubiquitous catabolic process that causes cellular bulk degradation of cytoplasmic components and is generally associated with positive effects on health and longevity. Inactivation of autophagy has been linked with detrimental effects on cells and organisms. The antagonistic pleiotropy theory postulates that some fitness-promoting genes during youth are harmful during aging. On this basis, we examined genes mediating post-reproductive longevity using an RNAi screen. From this screen, we identified 30 novel regulators of post-reproductive longevity, including pha-4. Through downstream analysis of pha-4, we identified that the inactivation of genes governing the early stages of…

0301 basic medicineAgingCytoplasmmedia_common.quotation_subjectLongevityVesicular Transport ProteinsContext (language use)Biology03 medical and health sciences0302 clinical medicinePleiotropyAutophagyGeneticsmedicineAnimalsGene SilencingCaenorhabditis elegansCaenorhabditis elegans ProteinsGenemedia_commonNeuronsGeneticsReproductionNeurodegenerationAutophagyLongevityGenetic Pleiotropymedicine.diseaseCell biology030104 developmental biologyCytoplasmSarcopeniaTrans-ActivatorsRNA InterferenceFunction and Dysfunction of the Nervous System030217 neurology & neurosurgerySignal TransductionResearch PaperDevelopmental BiologyGenes & Development
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Neuronal inhibition of the autophagy nucleation complex extends lifespan in post-reproductive C. elegans

2017

AbstractAutophagy is a ubiquitous catabolic process, which causes cellular bulk degradation of cytoplasmic components and thereby regulates cellular homeostasis. Inactivation of autophagy has been linked with detrimental effects to cells and organisms. The antagonistic pleiotropy theory postulates that fitness promoting genes during youth are harmful during aging (Williams 1957). On this basis we examined genes mediating post-reproductive longevity using an RNA interference screen. From this screen we identified 30 novel regulators of post-reproductive longevity including pha-4. Through downstream analysis of pha-4 we identify that genes governing the early stages of autophagy up until the …

0303 health sciencesmedia_common.quotation_subjectNeurodegenerationAutophagyLongevityCellular homeostasisContext (language use)Biologymedicine.diseaseCell biology03 medical and health sciences0302 clinical medicineRNA interferencePleiotropymedicineGene030217 neurology & neurosurgery030304 developmental biologymedia_common
researchProduct