0000000000217320

AUTHOR

Paolo Sbraccia

showing 4 related works from this author

“The Linosa Study”: Epidemiological and heritability data of the metabolic syndrome in a Caucasian genetic isolate

2009

Abstract Background and aims Growing evidence suggests that the metabolic syndrome (MetS) has both a genetic and environmental basis. To evaluate the possibility of a further genetic analysis, we estimated prevalence rates and heritabilities for the MetS and its individual traits in the adult population of Linosa, a small and isolated Italian Island in the southern-central part of the Mediterranean Sea. Methods and results The Linosa Study (LiS) group consisted of 293 Caucasian native subjects from 51 families (123 parents; 170 offsprings). The MetS was defined according to NCEP/ATP III criteria and the following prevalence rates were calculated: hyperglycaemia 20.3%; central obesity 34.9%;…

Blood GlucoseMaleSettore MED/09 - Medicina InternaGenetic LinkageEndocrinology Diabetes and MetabolismPrevalenceMedicine (miscellaneous)Settore MED/13 - EndocrinologiaGenetic Linkage; Young Adult; Age Factors; Metabolic Syndrome X; Cholesterol HDL; Hypertriglyceridemia; Sex Factors; Humans; Aged; Italy; Blood Glucose; Smoking; European Continental Ancestry Group; Adult; Middle Aged; Insulin Resistance; Adolescent; Male; FemaleSettore MED/49 - Scienze Tecniche Dietetiche ApplicateMetabolic SyndromeHypertriglyceridemiaeducation.field_of_studySettore M-EDF/01 - Metodi e Didattiche delle Attivita' MotorieNutrition and DieteticsMetabolic Syndrome XSmokingAge FactorsMiddle AgedCholesterolItalyAdolescent; Adult; Age Factors; Aged; Blood Glucose; Cholesterol HDL; European Continental Ancestry Group; Female; Genetic Linkage; Humans; Hypertriglyceridemia; Insulin Resistance; Italy; Male; Metabolic Syndrome X; Middle Aged; Sex Factors; Smoking; Young AdultFemaleCardiology and Cardiovascular MedicineGenetic isolateAdultmedicine.medical_specialtyWaistHDLAdolescentEuropean Continental Ancestry GroupPopulationBiologyWhite PeopleYoung AdultSex FactorsInsulin resistanceInternal medicinemedicineHumanseducationAgedCholesterol HDLnutritional and metabolic diseasesmetabolic syndromeHeritabilityInsulin resistanceMetabolic syndromeObesityHeritabilitymedicine.diseaseObesityEndocrinologySettore MED/03 - Genetica MedicaInsulin ResistanceMetabolic syndromeDemographyNutrition, Metabolism and Cardiovascular Diseases
researchProduct

SGK-1 protects kidney cells against apoptosis induced by ceramide and TNF-α

2015

AbstractCeramide regulates several different cellular responses including mechanisms leading to apoptosis. Serum- and glucocorticoid-inducible protein kinase (SGK)-1 is a serine threonine kinase, which activates survival pathways in response to stress stimuli. Recently, we demonstrated an anti-apoptotic role of SGK-1 in human umbilical endothelial cells treated with high glucose. In the present study, since ceramide induces apoptosis by multiple mechanisms in diabetes and its complication such as nephropathy, we aimed to investigate whether SGK-1 may protect even against apoptosis induced by ceramide in kidney cells. Human embryonic kidney (HEK)-293 cells stable transfected with SGK-1 wild …

Cancer ResearchProgrammed cell deathCeramideSettore MED/09 - Medicina InternaDIABETES MELLITUSImmunologyProtein Serine-Threonine KinasesTNF ALPHABiologyCeramidesKidneyTransfectionImmediate-Early ProteinsSettore MED/13 - EndocrinologiaCellular and Molecular Neurosciencechemistry.chemical_compoundHumansSettore MED/49 - Scienze Tecniche Dietetiche ApplicateProtein kinase ASettore MED/04 - Patologia GeneraleSerine/threonine-specific protein kinaseTumor Necrosis Factor-alphaCERAMIDEKinaseHEK 293 cellsKidney metabolismCell BiologyLipid signalingINSULINAPOPTOSIS3. Good healthCell biologyHEK293 CellschemistryINSULIN CERAMIDE DIABETES MELLITUS TNF ALPHA APOPTOSISOriginal ArticleCell Death & Disease
researchProduct

The three facets of the SARS-CoV-2 pandemic during the first two waves in the northern, central, and southern Italy

2023

Background: There is a scarcity of information in literature regarding the clinical differences and comorbidities of patients affected by Coronavirus disease 2019 (COVID-19), which could clarify the different prevalence of the outcomes (composite and only death) between several Italian regions. Objective: This study aimed to assess the heterogeneity of clinical features of patients with COVID-19 upon hospital admission and disease outcomes in the northern, central, and southern Italian regions. Methods: An observational cohort multicenter retrospective study including 1210 patients who were admitted for COVID-19 in Infectious diseases, Pulmonology, Endocrinology, Geriatrics and Internal Med…

COVID-19 Epidemiology Italy Mortality Public health SARS-CoV-2Infectious DiseasesSettore MED/09 - Medicina InternaPublic Health Environmental and Occupational HealthGeneral MedicineSettore MED/49 - Scienze Tecniche Dietetiche ApplicateSettore MED/13 - Endocrinologia
researchProduct

40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

2004

0303 health sciencesmedicine.medical_specialtybusiness.industryEASDEndocrinology Diabetes and MetabolismHuman physiologymedicine.disease03 medical and health sciences0302 clinical medicineDiabetes mellitusFamily medicineInternal MedicineMedicinebusiness030217 neurology & neurosurgery030304 developmental biology
researchProduct