0000000000217713

AUTHOR

Cristiano Alicino

showing 4 related works from this author

Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project

2019

Contains fulltext : 206779.pdf (Publisher’s version ) (Open Access) BACKGROUND: The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. METHODS: A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). RESULTS: During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candide…

MaleOutcome Assessmentlnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]MULTICENTERCritical Care and Intensive Care Medicinelaw.invention610 Medical sciences Medicine0302 clinical medicineRetrospective StudieRisk FactorslawOutcome Assessment Health CareEPIDEMIOLOGYMedicineCumulative incidencePREDICTORSCandidaMedicine(all)Cross InfectionIncidenceIncidence (epidemiology)lcsh:Medical emergencies. Critical care. Intensive care. First aidCandidiasisMiddle AgedIntensive care unitEuropeIntensive Care UnitsAbdominal candidiasis; Candida; Candidemia; Candidiasis; ICU; Incidence; Aged; Candidiasis Invasive; Cross Infection; Europe; Female; Humans; Incidence; Intensive Care Units; Male; Middle Aged; Outcome Assessment Health Care; Retrospective Studies; Risk FactorsCandidiasiFemaleSOFA scoreLife Sciences & BiomedicineHumanAbdominal candidiasismedicine.medical_specialtyInvasiveIntensive Care Unit610Abdominal candidiasis Candida Candidemia Candidiasis ICU Incidence03 medical and health sciencesCritical Care MedicineGeneral & Internal MedicineIntensive careSettore MED/41 - ANESTESIOLOGIAMANAGEMENTHumansCandidiasis InvasiveAgedRetrospective StudiesScience & TechnologyAbdominal candidiasis; Candida; Candidemia; Candidiasis; ICU; Incidencebusiness.industrySeptic shockINTRAABDOMINAL CANDIDIASISResearchCandidemia030208 emergency & critical care medicineRetrospective cohort studylcsh:RC86-88.9Odds ratiomedicine.diseaseHealth Carelnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]ICUEmergency medicineAbdominal candidiasibusinessCritical Care
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Risk Factors for Intra-Abdominal Candidiasis in Intensive Care Units: Results from EUCANDICU Study

2022

INTRODUCTION: Intra-abdominal infections represent the second most frequently acquired infection in the intensive care unit (ICU), with mortality rates ranging from 20% to 50%. Candida spp. may be responsible for up to 10-30% of cases. This study assesses risk factors for development of intra-abdominal candidiasis (IAC) among patients admitted to ICU. METHODS: We performed a case-control study in 26 European ICUs during the period January 2015-December 2016. Patients at least 18 years old who developed an episode of microbiologically documented IAC during their stay in the ICU (at least 48 h after admission) served as the case cohort. The control group consisted of adult patients who did no…

Microbiology (medical)MORTALITYInvasive candidiasiCandida; Intra-abdominal infection; Invasive candidiasis; Risk factorsCONTROLLED-TRIALCASPOFUNGINCANDIDEMIAInvasive candidiasisInfectious Diseaseslnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]Intra-abdominal infectionRisk factorsINFECTIONSMANAGEMENTEPIDEMIOLOGYPREDICTORSCONSENSUSCRITICALLY III PATIENTSCandida
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Trends of influenza B during the 2010–2016 seasons in 2 regions of north and south Italy: The impact of the vaccine mismatch on influenza immunisatio…

2017

Influenza A and B viruses are responsible for respiratory infections, representing globally seasonal threats to human health. The 2 viral types often co-circulate and influenza B plays an important role in the spread of infection. A 6-year retrospective surveillance study was conducted between 2010 and 2016 in 2 large administrative regions of Italy, located in the north (Liguria) and in the south (Sicily) of the country, to describe the burden and epidemiology of both B/Victoria and B/Yamagata lineages in different healthcare settings. Influenza B viruses were detected in 5 of 6 seasonal outbreaks, exceeding influenza A during the season 2012–2013. Most of influenza B infections were found…

Male0301 basic medicinevirusesInfluenza B viruDisease OutbreaksHuman health0302 clinical medicineRetrospective StudieEpidemiologyImmunology and Allergy030212 general & internal medicinehospitalChildSicilyB/Victoriaeducation.field_of_studyDisease OutbreakVaccinationvirus diseasesB/Victoria; B/Yamagata; community; hospital; Influenza type B; lineage; vaccine-mismatch; Immunology and Allergy; Immunology; Pharmacologyvaccine-mismatchInfluenza type BInfluenza A viruInfluenza A virusInfluenza VaccinesChild PreschoolcommunityCommunity settingFemaleSeasonsInfluenza VaccineHumanResearch Papermedicine.medical_specialty030106 microbiologyImmunologyPopulationEpidemic03 medical and health sciencesInfluenza HumanmedicineHumansEpidemicseducationRetrospective StudiesPharmacologyInfluenza immunisationbusiness.industryOutbreakInfluenza aVirologyInfluenza B virusVaccine mismatchSeasonbusinessB/YamagatalineageDemographyHuman Vaccines & Immunotherapeutics
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The molecular epidemiology and evolutionary dynamics of influenza B virus in two Italian regions during 2010-2015: The experience of Sicily and Ligur…

2016

Molecular epidemiology of influenza B virus remained poorly studied in Italy, despite representing a major contributor to seasonal epidemics. This study aimed to reconstruct the phylogenetic relationships and genetic diversity of the hemagglutinin gene sequences of 197 influenza B strains circulating in both Southern (Sicily) and Northern (Liguria) Italy between 2010 and 2015. Upper respiratory tract specimens of patients displaying symptoms of influenza-like illness were screened by real-time RT-PCR assay for the presence of influenza B virus. PCR-positive influenza B samples were further analyzed by sequencing. Neighbor-joining phylogenetic trees were constructed and the amino-acid alignm…

0301 basic medicineInfluenza ViruslineagesHemagglutinin Glycoproteins Influenza VirusLiguriaSettore MED/42 - Igiene Generale E Applicatamolecular epidemiologyCatalysilcsh:Chemistryviral evolutionCladeinfluenza BSicilylcsh:QH301-705.5PhylogenySpectroscopyPhylogenetic treeinfluenza B; lineages; viral evolution; surveillance; molecular epidemiology; influenza-like illness; Sicily; Liguria; ItalyComputer Science Applications1707 Computer Vision and Pattern RecognitionGeneral MedicineBiological EvolutionComputer Science ApplicationsInfluenza B; Influenza-like illness; Italy; Liguria; Lineages; Molecular epidemiology; Sicily; Surveillance; Viral evolution; Biological Evolution; Genetic Variation; Hemagglutinin Glycoproteins Influenza Virus; Humans; Influenza B virus; Influenza Human; Italy; Molecular Epidemiology; Sicily; Phylogeny; Catalysis; Molecular Biology; Computer Science Applications1707 Computer Vision and Pattern Recognition; Spectroscopy; Physical and Theoretical Chemistry; Organic Chemistry; Inorganic ChemistryInfluenza B; Influenza-like illness; Italy; Liguria; Lineages; Molecular epidemiology; Sicily; Surveillance; Viral evolution; Catalysis; Molecular Biology; Spectroscopy; Computer Science Applications1707 Computer Vision and Pattern Recognition; Physical and Theoretical Chemistry; Organic Chemistry; Inorganic ChemistryItalyViral evolutionsurveillanceHumanHemagglutinin Glycoproteinsinfluenza-like illnessHemagglutinin (influenza)BiologyArticleCatalysisVirusInorganic Chemistry03 medical and health sciencesLineagePhylogeneticsInfluenza HumanHumansPhysical and Theoretical ChemistryMolecular BiologyInfluenza-like illneInfluenza-like illnessMolecular epidemiologyOrganic ChemistryGenetic VariationVirologyInfluenzaInfluenza B virus030104 developmental biologylcsh:Biology (General)lcsh:QD1-999biology.protein
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