0000000000222700
AUTHOR
G. Anello
PROSPECTIVE, RANDOMIZED, CROSSOVER COMPARISON OF SUBLINGUAL APOMORPHINE (3 mg) WITH ORAL SILDENAFIL (50 mg) FOR MALE ERECTILE DYSFUNCTION
Abstract: Purpose: We established the efficacy and safety of sublingual apomorphine compared with oral sildenafil. in comparable groups of patients with erectile dysfunction (ED). Materials and Methods: This prospective, randomized, crossover study included 77 heterosexual men with ED of various etiologies and severities. A total of 62 men were randomized but only 34 were evaluable for efficacy and tolerability. The study started with a run-in period of 2 to 4 weeks. The first 4 weeks of treatment were followed by a washout period of 4 weeks, after which patients changed to the alternate treatment for an additional 4-week period. The sequence of the 2 treatments was established by a randomi…
Existence and multiplicity of solutions for Dirichlet problems involving nonlinearities with arbitrary growth.
In this article we study the existence and multiplicity of solutions for the Dirichlet problem $$\displaylines{ -\Delta_p u=\lambda f(x,u)+ \mu g(x,u)\quad\hbox{in }\Omega,\cr u=0\quad\hbox{on } \partial \Omega }$$ where $\Omega$ is a bounded domain in $\mathbb{R}^N$, $f,g:\Omega \times \mathbb{R}\to \mathbb{R}$ are Caratheodory functions, and $\lambda,\mu$ are nonnegative parameters. We impose no growth condition at $\infty$ on the nonlinearities f,g. A corollary to our main result improves an existence result recently obtained by Bonanno via a critical point theorem for $C^1$ functionals which do not satisfy the usual sequential weak lower semicontinuity property.