0000000000223857
AUTHOR
Devendra Singh
PHD3 regulates EGFR internalization and signalling in tumours
Tumours exploit their hypoxic microenvironment to induce a more aggressive phenotype, while curtailing the growth-inhibitory effects of hypoxia through mechanisms that are poorly understood. The prolyl hydroxylase PHD3 is regulated by hypoxia and plays an important role in tumour progression. Here we identify PHD3 as a central regulator of epidermal growth factor receptor (EGFR) activity through the control of EGFR internalization to restrain tumour growth. PHD3 controls EGFR activity by acting as a scaffolding protein that associates with the endocytic adaptor Eps15 and promotes the internalization of EGFR. In consequence, loss of PHD3 in tumour cells suppresses EGFR internalization and hy…
New national and regional bryophyte records, 42
1. Acaulon triquetrum (Spruce) Mull.Hal.Contributors: S. Grdovic, A. Sabovljevic and M.S. SabovljevicSerbia: Belgrade, Bežanijska kosa, on loess soil, 16 March 2013, leg./det. Aneta Sabovljevic & M...
Volume change characteristics of fine-grained soils due to sequential thermo-mechanical stresses
Know-how of volume change characteristics, VCC, of the fine-grained soils, exposed to thermal stresses, is essential for design of various thermo-active structures. These stresses are known to induce excess pore-water pressure, Δu θ , in the saturated state of such soils, which in turn affects their compression and shear strength characteristics. In this context, through several experimental studies, the effect of thermo-mechanical stress-path, the over-consolidation ratio (OCR) and degree of saturation on VCC (viz., thermally induced volumetric strain, ε vθ , compression and re-compression indices, c c and c r ) of the fine-grained soils has been demonstrated by earlier researchers. Howeve…