0000000000225642

AUTHOR

Benedetta Puccini

showing 2 related works from this author

Burkitt lymphoma with a granulomatous reaction: an M1/Th1‐polarised microenvironment is associated with controlled growth and spontaneous regression

2021

Aims Burkitt lymphoma (BL) is an aggressive B-cell lymphoma that, in some instances, may show a granulomatous reaction associated with a favourable prognosis and occasional spontaneous regression. In the present study, we aimed to define the tumour microenvironment (TME) in four such cases, two of which regressed spontaneously. Methods and results All cases showed aggregates of tumour cells with the typical morphology, molecular cytogenetics and immunophenotype of BL surrounded by a florid epithelioid granulomatous reaction. All four cases were Epstein-Barr virus (EBV)-positive with type I latency. Investigation of the TME showed similar features in all four cases. The analysis revealed a p…

MaleEpstein-Barr Virus InfectionsHerpesvirus 4 HumanHistologyAdolescentM1 polarised macrophagesTh1 T cellsExpressionBiologyT-Cell ResponsesVirusPathology and Forensic MedicineProinflammatory cytokineMolecular cytogeneticsOriginImmunophenotypingEBVM1 polarised macrophagehemic and lymphatic diseasesTumor MicroenvironmentmedicineHumansM1 polarized macrophagesAgedInhibitionMacrophagesBurkitt lymphomaBurkitt lymphoma; EBV; In Situ lymphoid neoplasia; M1 polarized macrophages; Microenvironment; Th1 T cells; granulomatous reactionB-CellsGeneral MedicineMiddle AgedTh1 Cellsmedicine.diseaseBurkitt LymphomamicroenvironmentRegressionLymphomain-situ lymphoid neoplasiagranulomatous reactionCancer researchFemaleTherapyCellular immunotherapyInfectionEarly phaseBurkitt lymphoma EBV granulomatous reaction in-situ lymphoid neoplasia M1 polarised macrophages microenvironment Th1 T cellsIn Situ lymphoid neoplasiaEpstein-Barr-VirusHistopathology
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Comprehensive geriatric assessment is an essential tool to support treatment decisions in elderly patients with diffuse large B-cell lymphoma: A pros…

2015

We performed a multicenter study to validate the concept that a simple comprehensive geriatric assessment (CGA) can identify elderly, non-fit patients with diffuse large B-cell lymphoma (DLBCL) in whom curative treatment is not better then palliation, and to analyze potential benefits of treatment modulation after further subdividing the non-fit category by CGA criteria. One hundred and seventy-three patients aged > 69 treated with curative or palliative intent by clinical judgement only were grouped according to CGA into fit (46%), unfit (16%) and frail (38%) categories. Two-year overall survival (OS) was significantly better in fit than in non-fit patients (84% vs. 47%; p < 0.0001).…

medicine.medical_specialtyCancer ResearchMultivariate analysisLymphomaChemotherapeutic approaches; Immunotherapy; Lymphoma and Hodgkin disease; Hematology; Oncology; Cancer ResearchMEDLINEDisease-Free SurvivalInternal medicineComprehensive Assesment Diffuse large B cell lymphomaAntineoplastic Combined Chemotherapy Protocolsmedicine80 and overLarge B-CellHumansProspective StudiesProspective cohort studyGeriatric AssessmentAgedAged 80 and overChemotherapeutic approachesbusiness.industryPalliative CareGeriatric assessmentHematologymedicine.diseasePrognosisDiffuseSurgeryLymphomaSettore MED/15 - MALATTIE DEL SANGUETreatment OutcomeMulticenter studyOncologyLymphoma and Hodgkin diseaseMultivariate AnalysisTreatment decision makingImmunotherapyLymphoma Large B-Cell DiffusebusinessDiffuse large B-cell lymphoma
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