0000000000230912

AUTHOR

Volker Schulz

showing 2 related works from this author

On the reproduceability of Kr-85 clearance curves. Simultaneous blood flow measurements on the rat kidney

1969

An Rattennieren wird in situ die Rindendurchblutung mit Hilfe der Kr-85-Auswaschtechnik bestimmt und mit der gleichzeitig direkt gemessenen Nierengesamtdurchblutung korreliert. Erfolgt die Auswertung der Clearancekurven nach dem Verfahren vonIngvar u.Lassen (1962), so erhalt man einen Korrelationskoeffizientenr=0.849, die Auswertung nachZierler (1965) ergibt einen Korrelationskoeffizientenr=0,545. Mit einem elektrischen Analogrechner durchgefuhrte Modellversuche zeigen, das die nachIngvar u.Lassen (1962) ermittelten Durchblutungswerte weder von der Dauer noch von der Form der sog. Eingangsfunktion, dem zeitlichen Verlauf, mit dem der Indikator im Sichtbereich des Detektors erscheint, abhang…

PhysicsPhysiologyPhysiology (medical)Clinical BiochemistryHuman physiologyMolecular biologyPfl�gers Archiv European Journal of Physiology
researchProduct

Preexisting musculoskeletal burden and its development under letrozole treatment in early breast cancer patients

2019

One of the most common adverse events (AEs) occurring during treatment with aromatase inhibitors (AIs) is musculoskeletal pain. The aim of our study was to analyze the influence of preexisting muscle/limb pain and joint pain on the development of AI-induced musculoskeletal AEs. Women eligible for upfront adjuvant endocrine therapy with letrozole were included in the PreFace study, a multicenter phase IV trial. During the first treatment year, they were asked to record musculoskeletal AEs monthly by answering questions regarding pain symptoms and rating the pain intensity on a numeric rating scale from 0 (no pain) to 10 (very strong pain). Pain values were compared using nonparametric statis…

Cancer Researchmedicine.medical_specialtyTime Factorsmedicine.drug_classMedizinBreast Neoplasms03 medical and health sciences0302 clinical medicineBreast cancerMusculoskeletal PainInternal medicinemedicineHumansIn patientAdverse effectAgedPain MeasurementEarly breast cancerAromatase inhibitorAromatase Inhibitorsbusiness.industryLetrozoleSignificant differenceMiddle Agedmedicine.diseaseArthralgiaPostmenopauseOncology030220 oncology & carcinogenesisJoint painLetrozoleFemalemedicine.symptombusinessmedicine.drugInternational Journal of Cancer
researchProduct