0000000000234618

AUTHOR

Silvia Aquila

showing 3 related works from this author

Anti-inflammatory activity of berenjenol and related compounds.

2008

Berenjenol ( 1), isolated from OXANDRA cf. XYLOPIOIDES (Annonaceae), was tested on two different experimental models of inflammation. The compound showed anti-inflammatory activity in the test of acute mouse ear edema induced by TPA (54 % inhibition, 1 μmol/ear) as well as in the test of subchronic inflammation induced by repeated application of TPA (57 % inhibition, 7 × 1 μmol/ear). Moreover, while it reduced the expression of both COX-2 (65 % inhibition at 50 μM) and iNOS (80 % inhibition at 50 μM), it was not active against TNF- α and IL-1 β in murine macrophages (RAW 264.7) stimulated with LPS. Structural modification of 1 gave two derivatives, berenjenol acetate ( 2) and 3-oxo-berenjen…

Lipopolysaccharidemedicine.drug_classInterleukin-1betaAnti-Inflammatory AgentsPharmaceutical ScienceAnnonaceaeGene ExpressionNitric Oxide Synthase Type IIPharmacologyAnti-inflammatoryAnalytical Chemistrychemistry.chemical_compoundMiceDrug DiscoverymedicineAnimalsEdemaProtein kinase CPharmacologybiologyDimethyl sulfoxideTumor Necrosis Factor-alphaMacrophagesOrganic ChemistryTriterpenesNitric oxide synthaseComplementary and alternative medicinechemistryBiochemistryCyclooxygenase 2biology.proteinMolecular MedicineTetradecanoylphorbol AcetateTumor necrosis factor alphaFemaleCyclooxygenaseFetal bovine serumPlanta medica
researchProduct

Anti-inflammatory activity of flavonoids from Cayaponia tayuya roots.

2008

Taiuiá or tayuya (Cayaponia tayuya, Cucurbitaceae) is a climbing, lignified plant with a large swollen root that has traditionally been used as an anti-inflammatory and anti-rheumatic agent in the folk medicine of Brazil, Peru, and Colombia.We have assayed the pharmacological properties of a flavonoid fraction obtained from the butanol extract of Cayaponia tayuya roots using two models of topical mouse ear oedema, paying special attention to its influence on the induction on pro-inflammatory enzymes and peptidic mediators.The in vivo experiments involved both the acute oedema induced by a single application of TPA and the subchronic inflammation brought on by repeated applications of TPA. T…

medicine.drug_classFlavonoidIsovitexinAnti-Inflammatory AgentsNitric Oxide Synthase Type IIPharmacologyPharmacognosyColombiaPlant RootsAnti-inflammatoryCell Linechemistry.chemical_compoundMiceWestern blotIn vivoDrug DiscoveryPerumedicineAnimalsPharmacologychemistry.chemical_classificationFlavonoidsInflammationbiologymedicine.diagnostic_testbusiness.industryPlant ExtractsMacrophagesbiology.organism_classificationCayaponia tayuyaCucurbitaceaeDisease Models AnimalchemistryBiochemistryCyclooxygenase 2biology.proteinFemaleCyclooxygenaseMedicine TraditionalbusinessBrazilJournal of ethnopharmacology
researchProduct

Inhibition of NF-κB Activation and iNOS Induction by ent-Kaurane Diterpenoids in LPS-Stimulated RAW264.7 Murine Macrophages

2009

Xerophilusin A (1), xerophilusin B (2), longikaurin B (3), and xerophilusin F (4) from Isodon xerophylus inhibit LPS-induced NO production in RAW 264.7 macrophages, with IC(50) values of 0.60, 0.23, 0.44, and 0.67 muM, respectively, and they all inhibited mRNA production in these same cells. They decreased the luciferase activity in RAW 264.7 cells transiently transfected with the NF-kappaB-dependent luciferase reporter, with IC(50) values of 1.8, 0.7, 1.2, and 1.6 muM, respectively. Compounds 1-3 reduced NF-kappaB activation, with compound 4 showing no effect, but p65 translocation from the cytoplasm to the nucleus and the LPS-induced degradation of IkappaB were inhibited by all four test …

LipopolysaccharidesIsodonNitric Oxide Synthase Type IIPharmaceutical ScienceChromosomal translocationNitric OxideAnalytical ChemistryMiceDrug DiscoverymedicineAnimalsLuciferaseLuciferasesPharmacologyPlants MedicinalbiologyMolecular StructureReverse Transcriptase Polymerase Chain ReactionMonocyteMacrophagesAnti-Inflammatory Agents Non-SteroidalOrganic ChemistryNF-kappa BBiological activityTransfectionbiology.organism_classificationMolecular biologyIn vitromedicine.anatomical_structureBiochemistryComplementary and alternative medicineCell cultureIsodonMolecular MedicineDiterpenesDiterpenes KauraneJournal of Natural Products
researchProduct