0000000000235083

AUTHOR

Iveta Vaivade

showing 2 related works from this author

BRCA1 gene-related hereditary susceptibility to breast and ovarian cancer in Latvia

2013

Abstract Purpose In this report, we summarise data on BRCA1 gene analysis in Latvia to characterise criteria of genetic testing for breast and ovarian cancer susceptibility. Material/methods Analysis by SSCP/HD, MALDI-TOF mass spectrometry or DNA sequencing was used for mutation detection. Mutations identified were confirmed by direct DNA sequencing. Results Out of 1068 breast and 231 ovarian cancer patients from different families: 58 carried the c.5266dupC and 43 carried the c.4035delA mutations. Every 4th patient in our study did not report cancer in the family. The breast cancer was diagnosed earlier in carriers of the c.5266dupC than in carriers of the c.4035delA ( p  = 0.003). The inc…

AdultOncologymedicine.medical_specialtyBreast NeoplasmsDiseasemedicine.disease_causePolymerase Chain ReactionBreast cancerInternal medicinemedicineHumansGenetic Predisposition to DiseaseFamily historyskin and connective tissue diseasesPolymorphism Single-Stranded ConformationalAgedGenetic testingAged 80 and overOvarian NeoplasmsMutationmedicine.diagnostic_testBRCA1 Proteinbusiness.industryCancerSingle-strand conformation polymorphismDNA NeoplasmGeneral MedicineMiddle AgedPrognosismedicine.diseaseLatviaMutationFemalebusinessOvarian cancerFollow-Up StudiesAdvances in Medical Sciences
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Polymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes

2013

Variations in the FTO gene and near the TMEM18 gene are risk factors for common form of obesity, but have also been linked with type 2 diabetes (T2D). Our aim was to investigate the contribution of these variants to risk of T2D in a population in Latvia. Four single nucleotide polymorphisms (SNP) in the first and fourth intronic regions of FTO and one close to TMEM18 were genotyped in 987 patients with T2D and 1080 controls selected from the Latvian Genome Data Base (LGDB). We confirmed association of SNPs in the first intron (rs11642015, rs62048402 and rs9939609) of FTO and rs7561317 representing the TMEM18 locus with T2D. Association between SNP in FTO and T2D remained significant after c…

Linkage disequilibriumendocrine system diseasesPopulationAlpha-Ketoglutarate-Dependent Dioxygenase FTOSingle-nucleotide polymorphismLocus (genetics)Genome-wide association studyBiologyPolymorphism Single NucleotideFTO geneGeneticsmedicineHumansSNPAge of OnseteducationGeneticseducation.field_of_studyAge FactorsMembrane ProteinsProteinsnutritional and metabolic diseasesGeneral Medicinemedicine.diseaseObesityDiabetes Mellitus Type 2Gene
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