Author: Ernest Graf

0000000000240608

AUTHOR

Ernest Graf

Protonation of a Spherical Macrotricyclic Tetramine: Water Inclusion, Allosteric Effect, and Cooperativity

The spherical macrotricyclic cryptand tetramine "C24" (1) displays remarkable protonation behaviour. It undergoes protonation in four successive steps for which pKa values of 11.17±0.05, 10.28±0.04, 6.00±0.06 and 3.08±0.08 have been determined at 298 K. The unusually close values for the first two protonations provide evidence for the encapsulation of a water molecule serving as effector for the second protonation, which is consistent with earlier observations that the exchange of protons bound in the diprotonated species with solvent protons is unusually slow and that 17 O NMR spectra show the presence of an oxygen centre in the same species quite distinct from that of solvent water. Encap…

research product

CCDC 1501082: Experimental Crystal Structure Determination

Related Article: Ernest Graf, Jack Harrowfield, Jean-Pierre Kintzinger, Jean-Marie Lehn, Jacques Le Moigne, Kari Rissanen|2018|ChemPlusChem|83|605|doi:10.1002/cplu.201700557

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PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
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LSLife Sciences
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