0000000000241390

AUTHOR

H. W. Kunz

showing 2 related works from this author

Dynamics of the localization of drug metabolizing enzymes in tissues and cells.

1984

MaleChemistryDynamics (mechanics)Rats Inbred StrainsBiochemistryEnzymesRatsIsoenzymesDrug metabolizing enzymesBiochemistryCytochrome P-450 Enzyme SystemLiverPharmaceutical PreparationsAnimalsFemaleGlutathione TransferaseBiochemical Society transactions
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Expression and inducibility of drug-metabolizing enzymes in preneoplastic and neoplastic lesions of rat liver during nitrosamine-induced hepatocarcin…

1987

The expression, inducibility, and regulation of four different cytochrome (cyt.) P-450 isoenzymes (PB1, PB2, MC1, and MC2) NADPH-cytochrome P-450 reductase, the glutathione transferases (GSTs) B and C and microsomal epoxide hydrolase (mEHb) have been studied during nitrosamine-induced hepatocarcinogenesis using immunohistochemical techniques. The investigations revealed basic differences in the expression of the individual drug metabolizing enzymes in the course of neoplastic development. While the two GSTs and mEHb were increased in all preneoplastic and benign neoplastic lesions, the levels of the distinct cyt. P-450 isoenzymes were characteristically different from each other. Following …

NitrosaminesCytochromeHealth Toxicology and MutagenesisReductaseToxicologyenvironment and public healthIsozymeMixed Function Oxygenaseschemistry.chemical_compoundLiver Neoplasms ExperimentalCytochrome P-450 Enzyme SystemAnimalsCytochrome P-450 Enzyme InhibitorsAdenosine Triphosphataseschemistry.chemical_classificationbiologyHistocytochemistryImmunochemistryProteinsRats Inbred StrainsGeneral MedicineMolecular biologyRatsenzymes and coenzymes (carbohydrates)Drug metabolizing enzymesEnzymeLiverchemistryBiochemistryNitrosamineEnzyme InductionMicrosomal epoxide hydrolaseembryonic structurescardiovascular systembiology.proteinImmunohistochemistryFemalePrecancerous ConditionsArchives of Toxicology
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