0000000000241392

AUTHOR

C. R. Wolf

showing 3 related works from this author

Dynamics of the localization of drug metabolizing enzymes in tissues and cells.

1984

MaleChemistryDynamics (mechanics)Rats Inbred StrainsBiochemistryEnzymesRatsIsoenzymesDrug metabolizing enzymesBiochemistryCytochrome P-450 Enzyme SystemLiverPharmaceutical PreparationsAnimalsFemaleGlutathione TransferaseBiochemical Society transactions
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Induction and suppression of cytochromes P-450 in rat tissues

1985

ChemistryBiochemistryBiochemical Society Transactions
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Measurement of substrate-induced oxygen uptake during microsomal drug oxidation using a gold micro-electrode.

1975

1. A resin-coated gold micro-electrode has been used for polarographic determination of oxygen concentration in liver microsomal suspensions from phenobarbital-pretreated rats. 2. The rate of oxygen uptake on addition of an NADPH-regenerating system and the rate after addition of various substrates of the mixed function oxidase system were measured. The rate of oxygen uptake was faster in the presence of substrate than in the presence of NADPH alone. 3. Kinetic constants (Km and V max) for biphenyl, hexobarbital, ethylmorphine, naphthalene and SKF 525-A measured by this technique compare favourably with those obtained either by measurements of NADPH oxidation, or chemical measurements of su…

MaleHealth Toxicology and MutagenesisInorganic chemistryHexobarbitalNaphthalenesToxicologyBiochemistryOxygen ConsumptionmedicineAnimalsPharmacologyPolarographyMorphine DerivativesCell-Free SystemMorphineChemistryProadifenBiphenyl CompoundsSubstrate (chemistry)General MedicineNADPH oxidationEthylmorphineRatsKineticsHexobarbitalMixed Function OxidaseMicrosomes LiverLimiting oxygen concentrationGoldOxidoreductasesMicroelectrodesOxidation-ReductionDrug metabolismNADPmedicine.drugPolarographyXenobiotica; the fate of foreign compounds in biological systems
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