0000000000244851
AUTHOR
A Bonura
DEVELOPMENT OF LIPID NANOSTRUCTURES CONTAINING A PARIETARIA POLLEN ALLERGEN.
GUARDARE PER LIVELLI: DAI SISTEMI AI COMPONENTI, DALLE PROPRIETÀ MACROSCOPICHE ALLE STRUTTURE MICROSCOPICHE
L'allergene maggiore di Parietaria judaica Parj 1.0101 contiene una regione capace di legare LPS e con attività immunomodulatoria
La spesa energetica a riposo è aumentata nei pazienti diabetici in scadente compenso ed è normalizzata dopo bolo di insulina
LPS challenge regulates gene expression and tissue localization of a Ciona intestinalis gene through an alternative polyadenylation mechanism
Isolation and characterization of a LPS induced MD2-like protein in Ciona intestinalis
The MD2 (Myeloid Differentiation factor-2) protein belongs to the ML superfamily. This group of proteins contain a specific lipid binding domain (ML domain) that plays an important role in lipid recognition and metabolism. In vertebrates, MD-2 is involved in innate immune response as co-receptor in the LPS/TLR4 signaling pathway; MD2 recognizes and binds the bacterial lipid A and drives the TLR4 activation. Two TLR isoforms, CiTLR-1 and CiTLR-2, were identified in Ciona intestinalis with a TIR domain most similar to human TLR4 and TLR 6 respectively. Using a PCR-based subtractive hybridization strategy for isolation of differentially expressed genes between LPS-challenged and naïve C. intes…
Attività immunomodulatoria del peptide PAR37 derivato dall'allergene maggiore di Parietaria judaica ParJ1.0101
Habitual street food intake and subclinical carotid atherosclerosis.
Street food (SF) is defined as out-of-home food consumption, and generally consists of energy-dense meals rich in saturated fats and poor in fibers, vitamins and antioxidants. Though SF consumption may have unfavorable metabolic and cardiovascular effects, its possible association with atherosclerosis has not been considered. The association between habitual SF consumption and asymptomatic carotid atherosclerosis, defined as the presence of plaques and/or increased intima-media thickness, was therefore investigated. One thousand thirty-five randomly selected adult participants without known diabetes and atherosclerotic cardiovascular diseases were cross-sectionally investigated in Palermo, …
Trattamento cronico con diuretici ed omeostasi glico-metabolica in un campione di adulti privi di diabete noto
A hybrid expressing engineered major allergens of the Parietaria pollen as a tool for Specific Allergy Vaccination
Impact of chronic diuretic treatment on glucose homeostasis
Background The use of diuretics for hypertension has been associated with unfavorable changes in cardiovascular risk factors, such as uric acid and glucose tolerance, though the findings in the literature are contradictory. Methods This study investigated whether diuretic use is associated with markers of metabolic and cardiovascular risk, such as insulin-resistance and uric acid, in a cohort of adults without known diabetes and/or atherosclerotic cardiovascular disease. Nine hundred sixty-nine randomly selected participants answered a questionnaire on clinical history and dietary habits. Laboratory blood measurements were obtained in 507 participants. Results Previously undiagnosed type 2 …
MICROSCOPIC AND MACROSCOPIC ASPECTS OF STUDENT KNOWLEDGE IN ELECTRIC CONDUCTION IN METALS
This paper presents some preliminary results of a research aimed at portraying individual models of description/explanation of electrical conduction in metals shown by physics prospective teachers and at studying how a specifically designed pedagogical environment can support an adequate evolution of their knowledge and disciplinary competencies. A teaching/learning sequence (TLS) on the subject matter, making use of custom Information Technology tools, aimed at facilitating and scaffolding learning, is shortly described. Some relevant points of the research pilot phases, like the analysis of prospective teachers’ spontaneous models of electrical conduction, the identification of significan…
Par j 1/Par j 2-nanoaggregati: un nuovo strumento per la terapia antiallergica
A pedagogical approach to the Boltzmann factor through experiments and simulations
The Boltzmann factor is the basis of a huge amount of thermodynamic and statistical physics, both classical and quantum. It governs the behaviour of all systems in nature that are exchanging energy with their environment. To understand why the expression has this specific form involves a deep mathematical analysis, whose flow of logic is hard to see and is not at the level of high school or college students' preparation. We here present some experiments and simulations aimed at directly deriving its mathematical expression and illustrating the fundamental concepts on which it is grounded. Experiments use easily available apparatuses, and simulations are developed in the Net-Logo environment…