0000000000245556

AUTHOR

Isabelle Batisson

Transcriptomic and proteomic responses of Microbacterium sp. C448 exposed to sulfamethazine antibiotic

International audience; The Microbacterium sp. C448 was isolated from a soil regularly exposed to sulfamethazine(SMZ), for its ability to partly mineralise this antibiotic and other related sulfonamides.The aim of our study was to explore its metabolic adaptation towards exposure to SMZenvironmental (10 mg/L) and medicinal (250 mg/L) concentrations. Its transcriptomic andproteomic responses were analysed by focusing on the degradation regulon (sad genes) andresistance genes (folP and sul1).The transcriptomic and proteomic results were essentially congruent whatever theconcentrations tested. In culture conditions, exposure to the highest concentration of SMZ led tothe highest sad expression …

research product

Metabolic response of Microbacterium sp. C448 exposed to environmental and medicinal concentrations of sulfamethazine antibiotic

International audience

research product