0000000000245768

AUTHOR

Francesca Mangialasche

showing 8 related works from this author

Lymphocytic Mitochondrial Aconitase Activity is Reduced in Alzheimer's Disease and Mild Cognitive Impairment

2015

Background: Specific mechanisms behind the role of oxidative/nitrosative stress and mitochondrial dysfunction in Alzheimer's disease (AD) pathogenesis remain elusive. Mitochondrial aconitase (ACO2) is a Krebs cycle enzyme sensitive to free radicalmediated damage. Objective: We assessed activity and expression of ACO2 extracted from blood lymphocytes of subjects with AD, mild cognitive impairment (MCI), older adults with normal cognition (OCN, age >= 65 years), and younger adults with normal cognition (YCN, age < 65 years). Plasma levels and activities of antioxidants were also measured. Methods: Blood samples were collected from 28 subjects with AD, 22 with MCI, 21 OCN, and 19 YCN. ACO2 act…

MalePathologyantioxidantAntioxidantmedicine.medical_treatmentLymphocyteMitochondrionmedicine.disease_causePolymerase Chain ReactionPathogenesisVitamin Eoxidative stressLymphocytesaconitase (aconitate hydratase)Aconitate Hydratasereactive oxygen speciesGeneral NeuroscienceACO2General MedicineAlzheimer's diseasemitochondriaPsychiatry and Mental healthClinical Psychologyantioxidantsmedicine.anatomical_structureDisease ProgressionSettore MED/26 - NeurologiaFemaleAlzheimer diseaseAlzheimer's diseaseAzheimer diseasereactive nitrogen speciemedicine.medical_specialtyaconitase (aconitate hydratase); Alzheimer disease; antioxidants; free radicals; lymphocyte; mild cognitive impairment; mitochondria; oxidative stress; reactive nitrogen species; reactive oxygen speciesBlotting Westernfree radicalslymphocytemild cognitive impairmentInternal medicinemedicineHumansCognitive DysfunctionRNA MessengerAgedfree radicaloxidative strebusiness.industryVitamin EAconitasimedicine.diseasereactive nitrogen speciesEndocrinologyGeriatrics and GerontologyAlzheimer's disease; Aconitasi; oxidative stress; Aconitase (aconitate hydratase) Azheimer disease antioxidants free radicals lymphocyte mild cognitive impairment mitochondria oxidative stress reactive nitrogen species reactive oxygen speciesMental Status SchedulebusinessBiomarkersOxidative stressJournal of Alzheimer's Disease
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Neuropsychiatric symptoms in 921 elderly subjects with dementia: a comparison between vascular and neurodegenerative types.

2008

Objective:  i) to describe the neuropsychiatric profile of elderly subjects with dementia by comparing vascular (VaD) and degenerative dementias, i.e. dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD); ii) to assess whether the severity and type of dementia are associated with clinically relevant neuropsychiatric symptoms (CR-NPS). Method:  One hundred and thirty-one out-patients with VaD, 100 with DLB and 690 with AD were studied. NPS were evaluated by the neuropsychiatric inventory (NPI). Results:  Vascular dementia had lower total and domain-specific NPI scores and a lower frequency of CR-NPS than AD and DLB, for which frequency of CR-NPS increased significantly with disease s…

Lewy Body DiseaseMalemedicine.medical_specialtyPathologyPsychometricsDiseaseNeuropsychological TestsCentral nervous system diseaseDegenerative diseaseAlzheimer DiseaseInternal medicinemental disordersmedicineDementiaHumansVascular dementiaAgedAged 80 and overLewy bodyDementia with Lewy bodiesDementia Vasculartechnology industry and agricultureReproducibility of Resultsneuropsychiatric symptoms vascular dementia dementia with Lewy bodies Alzheimer’s disease dementia severitymedicine.diseasePsychiatry and Mental healthnervous systemDisease ProgressionSettore MED/26 - NeurologiaFemaleAlzheimer's diseasePsychologyActa psychiatrica Scandinavica
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Cognitive performance in elderly patients undergoing carotid endarterectomy or carotid artery stenting: a twelve-month follow-up study

2010

&lt;i&gt;Background:&lt;/i&gt; It is still a matter of debate if and to what extent carotid endarterectomy (CEA) and carotid artery stenting (CAS) impair cognitive functioning in the elderly. &lt;i&gt;Methods:&lt;/i&gt; We conducted a nonrandomized clinical trial on subjects with asymptomatic carotid artery stenosis comparing CEA (n = 28; 24 males and 4 females; 72.6 ± 5.8 years old) with CAS (n = 29; 17 males and 12 females; 75.1 ± 5.7 years old). Cognition, mood and functional status were evaluated by a broad spectrum of tests performed on the day prior to carotid reopening as well as 3 and 12 months after. &lt;i&gt;Results:&lt;/i&gt; No significant differences in scores on cognitive test…

Malemedicine.medical_specialtyCarotid arteriesmedicine.medical_treatmentMEDLINECarotid endarterectomyNeuropsychological TestsCognitionMemoryInternal medicinecarotid endoarterectomymedicineHumansAttentionCarotid Stenosiscardiovascular diseasesEffects of sleep deprivation on cognitive performancecognitive performanceAgedEndarterectomyEndarterectomy Carotidcarotid artery stentingcognitive performance; carotid endoarterectomy; carotid artery stentingbusiness.industryCognitionhumanitiesSurgeryClinical trialAffectNeurologycardiovascular systemCardiologyFemaleStentsSettore MED/26 - NeurologiaNeurology (clinical)Cardiology and Cardiovascular MedicinebusinessFollow-Up StudiesMonth follow up
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A systematic review of neuropsychiatric symptoms in mild cognitive impairment.

2009

Mild cognitive impairment (MCI) is a clinical concept proposed as an intermediate state between normal aging and dementia. This condition has multiple heterogeneous sources, including clinical presentation, etiology, and prognosis. Recently, the prevalence and associated features of neuropsychiatric symptoms (NPS) in MCI have been described. We systematically searched the PubMed database (last accessed on August 31, 2008) for articles on NPS in MCI. Included articles used strict selection criteria, and outcome variables were extracted in duplicate; of the 27 articles included, 14 (52%) used prospective cohorts. The global prevalence of NPS in MCI ranged from 35% to 85%. The most common beha…

medicine.medical_specialtyPopulationDiseaseNeuropsychological TestsIrritabilitybehavioral disciplines and activitiesAlzheimer DiseaseRisk FactorsInternal medicinemental disordersmedicineDementiaAlzheimer’s disease behavior dementia depression incidence mild cognitive impairment neuropsychiatric symptoms predictors prevalence risk factorsHumansProspective cohort studyeducationDepression (differential diagnoses)education.field_of_studyClinical Trials as TopicGeneral NeuroscienceMental DisordersGeneral Medicinemedicine.diseasePsychiatry and Mental healthClinical PsychologyEtiologyAnxietySettore MED/26 - NeurologiaGeriatrics and Gerontologymedicine.symptomPsychologyCognition DisordersClinical psychologyJournal of Alzheimer's disease : JAD
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Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment

2009

Alzheimer's disease (AD) is the most common type of dementia in the elderly. Products of oxidative and nitrosative stress (OS and NS, respectively) accumulate with aging, which is the main risk factor for AD. This provides the basis for the involvement of OS and NS in AD pathogenesis. OS and NS occur in biological systems due to the dysregulation of the redox balance, caused by a deficiency of antioxidants and/or the overproduction of free radicals. Free radical attack against lipids, proteins, sugars and nucleic acids leads to the formation of bioproducts whose detection in fluids and tissues represents the currently available method for assessing oxidative/nitrosative damage. Post-mortem …

AgingPathologymedicine.medical_specialtyFree RadicalsAlzheimer’s disease Mild cognitive impairment Free radicals Nitrosative stress Oxidative stressBioenergeticsDiseaseOxidative phosphorylationmedicine.disease_causeBiochemistryPathogenesisAlzheimer DiseaseHumansMedicineDementiaMolecular BiologyFree-radical theory of agingbusiness.industryMetabolismmedicine.diseaseOxidative StressNeurologyImmunologySettore MED/26 - NeurologiaCognition DisordersReactive Oxygen SpeciesbusinessBiomarkersOxidative stressBiotechnology
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How can dementia and disability be prevented in older adults: where are we today and where are we going?

2021

Abstract Ageing of the population, together with population growth, has brought along an ample increase in the number of older individuals living with dementia and disabilities. Dementia is the main cause of disability in old age, and promoting healthy brain ageing is considered as a key element in diminishing the burden of age‐related disabilities. The World Health Organization recently launched the first risk reduction guidelines for cognitive impairment and dementia. According to recent estimates, approximately 40% of dementia cases worldwide could be attributable to 12 modifiable risk factors: low education; midlife hypertension and obesity; diabetes, smoking, excessive alcohol use, phy…

0301 basic medicineGerontologyPhysical disabilityPopulationReviewsReview030204 cardiovascular system & hematologyehkäisevä lääketiedelaw.invention03 medical and health sciences0302 clinical medicineRandomized controlled trialpreventiontoimintakykylawRisk FactorsIntervention (counseling)Health careliikuntakykyInternal MedicineMedicineDementiaHumansCognitive DysfunctioneducationLife StyleDepression (differential diagnoses)cognitive impairmentAgedRandomized Controlled Trials as Topicmuistisairaudeteducation.field_of_studybusiness.industrymuscle physiologyliikuntarajoitteetCognitionriskitekijätmedicine.disease3. Good healthikääntyminen030104 developmental biologyageingDementiabusinessRisk Reduction BehaviorikääntyneetdementiaJournal of Internal Medicine
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Validation study of the Italian Addenbrooke’s Cognitive Examination Revised in a young-old and old-old population

2011

&lt;i&gt;Aims:&lt;/i&gt; The main aims of the study were the translation and the subsequent validation in Italian of the Addenbrooke’s Cognitive Examination Revised (ACE-R), and the evaluation of its usefulness in discriminating cognitively normal subjects from patients with mild dementia in an elderly population. &lt;i&gt;Methods:&lt;/i&gt; The ACE-R was translated and adapted into Italian. The Italian ACE-R was administered to a group of 179 elderly subjects (72 cognitively healthy and 107 subjects with mild dementia, mean age 75.4 ± 6.4 years). The group was stratified into two subsamples according to age, i.e. a young-old (&lt;75 years) and an old-old (≧75 years) group, in order to eval…

GerontologyCross-Cultural ComparisonLewy Body DiseaseMaleValidation studyPsychometricsPsychometricsCognitive NeurosciencePopulationNeuropsychological TestsElderlyCognitive assessmentAlzheimer DiseaseReference ValuesHumansDementia diagnosisCognitive DysfunctionAddenbrooke’s cognitive examination; Elderly; Dementia; Cognitive assessment; Young-old; Old-oldeducationAgedAged 80 and overeducation.field_of_studyAddenbrooke’s cognitive examinationDementia VascularReproducibility of ResultsTranslatingAddenbrooke's cognitive examinationPsychiatry and Mental healthItalyReference valuesFrontotemporal DementiaAddenbrooke’s cognitive examination Elderly Dementia Cognitive assessment Young-old Old-oldSettore MED/26 - NeurologiaFemaleDementiaYoung-oldOld-oldCognitive Assessment SystemGeriatrics and GerontologyPsychologyLewy body diseaseMental Status Schedule
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Performance cognitive in pazienti anziani sottoposti a endoarterectomia o a stenting carotideo: Studio di follow up a 12 mesi

2010

Introduction. In this study we investigated short and long-term impact of carotid endarterectomy (CEA) and carotid artery stenting (CAS) in cognitively healthy elderly subjects with severe carotid stenosis on several cognitive functions by neuropsychological evaluation before surgery and after three and twelve months. Methods. Cognition, mood and functional status were evaluated in 28 patients undergoing CEA (24 M, 4 F, 72.6 ± 5.8 years old) and in 29 patients undergoing CAS (17 M, 12 F, 75.1 ± 5.7 years old) by a broad spectrum of tests assessing mood, functional status, memory, attention, verbal fluency, visuospatial and constructional abilities. Results. No significant differences in s…

AgingArtery stentingCarotid endarterectomySettore MED/26 - NeurologiaGeriatrics and GerontologyCognitive performanceElder
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