0000000000246813

AUTHOR

Kristi L. Kiick

showing 2 related works from this author

A Versatile Grafting-to Approach for the Bioconjugation of Polymers to Collagen-like Peptides Using an Activated Ester Chain Transfer Agent

2009

DepartmentofMaterials Science and Engineering, University of Delaware, 201DuPont Hall, Newark, Delaware 19716,Received February 24, 2009Revised Manuscript Received April 24, 2009Biohybrid materials consisting of synthetic polymers andbiological moieties have gained more and more interest in therecent years.

chemistry.chemical_classificationBioconjugationPolymers and PlasticsChemistryScience and engineeringOrganic ChemistryRadical polymerizationChain transferPolymerGraftingInorganic Chemistrychemistry.chemical_compoundChemical couplingMaterials ChemistryPeptide synthesisOrganic chemistryMacromolecules
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Morphological transformations in a dually thermoresponsive coil-rod-coil bioconjugate.

2013

We report the conformational and assembly behavior of a thermoresponsive triblock biohybrid conjugate under aqueous conditions. The triblock comprises of poly(diethylene glycol methyl ether methacrylate) (PDEGMEMA) conjugated to the ends of a triple-helix forming collagen-like peptide. The circular dichroism (CD) experiment confirms the ability of the collagen-like peptide middle block to assemble as a triple helix in the hybrid conjugate. Above the LCST (∼35 °C), the collapse of the thermoresponsive PDEGMEMA polymer at the ends of the peptide domain resulted in a concomitant increase in the conformational stability of the peptide domain towards thermal denaturation. Upon cooling back, the …

chemistry.chemical_classificationCircular dichroismChemistryGeneral ChemistryPolymerCondensed Matter PhysicsMethacrylateLower critical solution temperatureArticleCrystallographyTransmission electron microscopyPolymer chemistryStatic light scatteringConjugateTriple helixSoft matter
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