0000000000247826

AUTHOR

Michele Andreucci

showing 5 related works from this author

Prevalence and severity of anaemia in patients with type 2 diabetic nephropathy and different degrees of chronic renal insufficiency.

2007

<i>Background/Aim:</i> Type 2 diabetes mellitus is the single most common cause of chronic kidney disease (CKD); however its real impact on renal anaemia has not been established. The aim of this study was to evaluate whether onset, severity, and prevalence of anaemia during the course of CKD is different between type 2 diabetic and non-diabetic patients. <i>Methods:</i> We enrolled 281 patients with: (1) type 2 diabetes and no CKD (n = 75); (2) type 2 diabetes plus CKD (n = 106), and (3) CKD without type 2 diabetes (n = 100). According to K/DOQI guidelines, the patients with renal insufficiency (i.e., those with a glomerular filtration rate <60 ml/min) were subgr…

NephrologyMaleglomerulus filtration rateType 2 diabetesurologic and male genital diseasesGastroenterologySeverity of Illness Indexadult; aged; anemia; article; chronic kidney failure; comparative study; controlled study; creatinine clearance; diabetic nephropathy; disease course; disease severity; female; glomerulus filtration rate; hemoglobin blood level; human; kidney failure; kidney function; major clinical study; male; non insulin dependent diabetes mellitus; practice guideline; prevalence; priority journal; risk assessment; Aged; Anemia; Creatinine; Diabetes Mellitus Type 2; Diabetic Nephropathies; Female; Glomerular Filtration Rate; Hemoglobins; Humans; Kidney Failure Chronic; Male; Middle Aged; Prevalence; Severity of Illness Index; Sex DistributionKidney FailureDiabetic nephropathychemistry.chemical_compoundHemoglobinsChronic kidney diseasecreatinine clearancePrevalenceDiabetic NephropathiesChronickidney functioncomparative studynon insulin dependent diabetes mellitusadultdisease coursearticlerisk assessmentAnemiaGeneral Medicinechronic kidney failureMiddle Agedpriority journalNephrologyCreatininedisease severityFemaleType 2Glomerular Filtration Ratemedicine.medical_specialtyAnaemia diabetes mellitus; Chronic kidney disease diabetes mellitus; Type 2 diabetes mellitus anaemiaRenal functionAnaemiaDiabetes mellitusInternal medicineType 2 diabetes mellitusDiabetes MellitusmedicineHumanscontrolled studyhumanSex DistributionAgedSettore MED/14 - NefrologiaCreatininehemoglobin blood levelbusiness.industrydiabetic nephropathypractice guidelineType 2 Diabetes Mellitusmedicine.diseasemajor clinical studySurgerychemistryDiabetes Mellitus Type 2Kidney Failure ChronicbusinessKidney disease
researchProduct

Serum alkaline phosphatase negatively affects endothelium-dependent vasodilation in naïve hypertensive patients.

2015

Tissue nonspecific alkaline phosphatase, promoting arterial calcification in experimental models, is a powerful predictor of total and cardiovascular mortality in general population and in patients with renal or cardiovascular diseases. For this study, to evaluate a possible correlation between serum alkaline phosphatase levels and endothelial function, assessed by strain gauge plethysmography, we enrolled 500 naïve hypertensives divided into increasing tertiles of alkaline phosphatase. The maximal response to acetylcholine was inversely related to alkaline phosphatase ( r =−0.55; P <0.001), and this association was independent ( r =−0.61; P <0.001) of demographic and classical risk …

Malemedicine.medical_specialtyEndotheliumPopulationRenal functionchemistry.chemical_elementVasodilationCalciumFollow-Up StudieatherosclerosiRisk FactorsInternal medicineInternal MedicinemedicineHumansEndothelial dysfunctioneducationriskeducation.field_of_studybusiness.industryRisk FactorMedicine (all)IncidenceMiddle Agedmedicine.diseaseAlkaline PhosphataseacetylcholinePlethysmographyVasodilationmedicine.anatomical_structureEndocrinologychemistryItalyHypertensionAlbuminuriaAlkaline phosphataseFemaleacetylcholine; alkaline phosphatase; atherosclerosis; hypertension; riskEndothelium Vascularatherosclerosismedicine.symptombusinessHumanFollow-Up StudiesHypertension (Dallas, Tex. : 1979)
researchProduct

Progression of coronary artery calcification and cardiac events in patients with chronic renal disease not receiving dialysis

2011

We tested for the presence of coronary calcifications in patients with chronic renal disease not on dialysis and studied its progression in 181 consecutive non-dialyzed patients who were followed for a median of 745 days. Coronary calcifications (calcium score) were tallied in Agatston units by computed tomography, and the patients were stratified into two groups by their baseline calcium score (100 U or less and over 100 U). Survival was measured by baseline calcium score and its progression. Cardiac death and myocardial infarction occurred in 29 patients and were significantly more frequent in those patients with calcium scores over 100 U (hazard ratio of 4.11). With a calcium score of 10…

AdultMaleNephrologymedicine.medical_specialtySettore MED/09 - Medicina Internamedicine.medical_treatmentMyocardial Infarctioncardiovascular events chronic kidney disease coronary calcificationCoronary Artery DiseaseKaplan-Meier EstimateCohort StudiesCoronary artery diseasecardiovascular eventsRisk FactorsCalcinosisInternal medicinemedicineHumansMyocardial infarctionRenal Insufficiency ChronicDialysisAgedSettore MED/14 - Nefrologiabusiness.industryHazard ratiocoronary calcificationCalcinosisMiddle AgedPrognosismedicine.diseasecardiovascular eventSettore MED/45 - Scienze Infermieristiche Generali Cliniche E PediatricheSettore MED/11 - Malattie Dell'Apparato CardiovascolareSurgeryNephrologyDisease ProgressionCardiologyFemaleOriginal Articlebusinesschronic kidney diseaseKidney diseaseCalcification
researchProduct

P1003STUDY DESIGN OF THE ROTATION FOR OPTIMAL TARGETING OF ALBUMINURIA AND TREATMENT EVALUATION (ROTATE-3): A ROTATION STUDY OF DIFFERENT ALBUMINURIA…

2020

Abstract Background and Aims Patients with diabetic kidney disease show a wide variability in their response to established and new treatments. SGLT2 inhibitors have also shown to slow the progression of kidney disease. Some studies have also shown kidney benefits for Mineralocorticoid Receptor Antagonists (MRA). A large outcome trial with the MRA finerenone is currently ongoing to assess effects of this MRA on major kidney outcomes. The individual trials will solve the issue whether a patient may have benefit from an SGLT2 inhibitor or MRA, but they do not address the key question which of the two or their combination is better to reduce albuminuria for each individual patient. Therefore, …

Transplantationmedicine.medical_specialtybusiness.industryUrologyRotationmedicine.diseaseEplerenoneDiabetic nephropathychemistry.chemical_compoundBlood pressurechemistryNephrologyDiabetes mellitusmedicineDrug responseAlbuminuriaDapagliflozinmedicine.symptombusinessmedicine.drugNephrology Dialysis Transplantation
researchProduct

Sympathovagal balance and 1-h postload plasma glucose in normoglucose tolerant hypertensive patients.

2015

AIMS: Normoglucose tolerant (NGT) subjects with a 1-h postload plasma glucose (PLPG) value ≥155 mg/dL have an increased risk of type-2 diabetes and subclinical organ damage. Heart rate variability (HRV) reflects cardiac autonomic balance, frequently impaired in course of diabetes. At this time, no data support the association between 1-h PLPG and HRV; thus, we investigated the possible association between 1-h PLPG and HRV. METHODS: We enrolled 92 never-treated hypertensive subjects (56 women, 36 men), aged 55 ± 9.8 years. During OGTT, the patients underwent electrocardiographic recordings to evaluate HRV in the time domain (SDNN). Insulin sensitivity was assessed by Matsuda index. RESULTS: …

AdultBlood GlucoseMalemedicine.medical_specialtySettore MED/09 - Medicina Internaendocrine system diseasesglucose toleranceInsulin resistance Heart rate variability Glucose tolerance Essential hypertensionEndocrinology Diabetes and Metabolismmedicine.medical_treatment030209 endocrinology & metabolism030204 cardiovascular system & hematologyEssential hypertensionAutonomic Nervous Systeminsulin resistance heart rate variability glucose tolerance essential hypertensionImpaired glucose tolerance03 medical and health sciences0302 clinical medicineEndocrinologyInsulin resistanceHeart RateInternal medicineDiabetes mellitusinsulin resistanceGlucose IntoleranceInternal MedicineMedicineHeart rate variabilityHomeostasisHumansSubclinical infectionBalance (ability)Agedbusiness.industryInsulinheart rate variabilityessential hypertensionnutritional and metabolic diseasesGeneral MedicineGlucose Tolerance TestMiddle Agedmedicine.diseaseEndocrinologyDiabetes Mellitus Type 2HypertensionCardiologyFemalebusinesshormones hormone substitutes and hormone antagonists
researchProduct