0000000000247844

AUTHOR

Seyed Mohammadali Dadfar

showing 2 related works from this author

Influence of Riboflavin Targeting on Tumor Accumulation and Internalization of Peptostar Based Drug Delivery Systems.

2020

Riboflavin carrier protein (RCP) and riboflavin transporters (RFVTs) have been reported to be highly overexpressed in various cancer cells. Hence, targeting RCP and RFVTs using riboflavin may enhance tumor accumulation and internalization of drug delivery systems. To test this hypothesis, butyl-based 3-arm peptostar polymers were synthesized consisting of a lysine core (10 units per arm) and a sarcosine shell (100 units per arm). The end groups of the arms and the core were successfully modified with riboflavin and the Cy-5.5 fluorescent dye, respectively. While in phosphate buffered saline the functionalized peptostars showed a bimodal behavior and formed supramolecular structures over tim…

SarcosinePolymersmedia_common.quotation_subjectRiboflavinLysineBiomedical EngineeringPharmaceutical ScienceBioengineeringRiboflavinchemistry.chemical_compoundIn vivoRiboflavin-carrier proteinMaterials TestingHumansInternalizationmedia_commonPharmacologyDrug CarriersChemistryLysineOrganic ChemistryMembrane Transport ProteinsBiological TransportSarcosineCarbocyaninesCancer cellDrug deliveryPC-3 CellsBiophysicsBiotechnologyBioconjugate chemistry
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Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance.

2020

Journal of nanobiotechnology 18, 22 (2020). doi:10.1186/s12951-020-0580-1

Hyperthermialcsh:Medical technologyMaterials sciencelcsh:BiotechnologyDispersityBiomedical EngineeringIron oxidePharmaceutical ScienceMedicine (miscellaneous)NanoparticleContrast MediaBioengineering02 engineering and technology010402 general chemistry01 natural sciencesApplied Microbiology and BiotechnologyTheranostic Nanomedicinechemistry.chemical_compoundStructure-Activity RelationshipIron oxide nanoparticlesMagnetic particle imagingDynamic light scatteringlcsh:TP248.13-248.65medicineHumansHyperthermiaParticle SizeMagnetite Nanoparticlesmedicine.diagnostic_testResearchSPIONMagnetic resonance imagingDextransHyperthermia Induced021001 nanoscience & nanotechnologymedicine.diseaseImage EnhancementMagnetic Resonance Imaging0104 chemical scienceslcsh:R855-855.5chemistryMolecular MedicineMPI0210 nano-technologyIron oxide nanoparticlesBiomedical engineeringMRIJournal of nanobiotechnology
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