0000000000247934

AUTHOR

Caterina Corace

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Anti-C1q Autoantibodies in Lupus Nephritis: Prevalence and Clinical Significance

2005

Recently, anti-C1q autoantibodies have been proposed as a useful marker in systemic lupus erythematosus (SLE) since their occurrence correlates with renal involvement and, possibly, with nephritic activity. We aimed to evaluate the prevalence of anti-C1q antibodies in patients with SLE, with and without renal involvement, and to correlate these markers' presence and levels with the activity of the disease and nephropathy. We studied 61 patients with SLE, 40 of whom had biopsy-proven lupus nephritis; 35 patients with other connective tissue diseases; and 54 healthy controls. In addition, 18 lupus nephritis patients were followed up during the disease time course. Anti-C1q antibodies were mea…

BiopsySLELupus nephritisEnzyme-Linked Immunosorbent AssaySystemic lupus erythematosuAnti-DNA antibodieSeverity of Illness IndexGeneral Biochemistry Genetics and Molecular BiologyFollow-Up StudieNephropathyCohort StudiesHistory and Philosophy of Scienceimmune system diseasesAutoimmune diseasePrevalencemedicineHumansLupus Erythematosus SystemicConnective Tissue DiseasesGlomerulonephritiskin and connective tissue diseasesRenal flareConnective Tissue DiseaseAutoantibodiesAutoimmune diseaseBiochemistry Genetics and Molecular Biology (all)Systemic lupus erythematosusbusiness.industryLupus nephritiComplement C1qGeneral NeuroscienceAutoantibodyGlomerulonephritisBiomarkermedicine.diseaseLupus NephritisAutoantibodieAntibodies Anti-IdiotypicItalyAntibodies AntinuclearImmunologyAnti-C1q antibodieCohort StudiebusinessNephritisBiomarkersFollow-Up StudiesHumanAnti-SSA/Ro autoantibodiesAnnals of the New York Academy of Sciences
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