0000000000248024

AUTHOR

Luciano Milanesi

showing 3 related works from this author

Genome Sequence of Rhodococcus sp. Strain BCP1, a Biodegrader of Alkanes and Chlorinated Compounds

2013

Rhodococcus sp. strain BCP1 (DSM 44980) co-metabolizes chlorinated compounds and mineralizes a broad range of alkanes being highly tolerant to these toxic chemicals. Here, we present the high-quality draft genome sequence of strain BCP1 consisting of 6,231,823 bp, with a G+C content of 70.4%, 5,902 protein-coding genes, and 58 RNAs genes. Rhodococcus genus comprises Gram-positive, non-sporulating, aerobic bacteria that are widely distributed in the environment (1). Rhodococcus sp. strain BCP1 (formerly: Rhodococcus aetherovorans strain BCP1, DSM 44980) was selected from an aerobic butane-utilizing consortium as the prevailing isolate able to co-metabolize chloroform, vinyl chloride and tric…

Whole genome sequencingRHODOCOCCUSRhodococcus genome sequencingStrain (chemistry)StereochemistryGENOME SEQUENCERNABiologyBiodegradationBIO/19 - MICROBIOLOGIA GENERALEGenomeCHLORINATED SOLVENTSMicrobiologynot availableN-ALKANESGeneticsProkaryotesMicrobial biodegradationMolecular BiologyGeneRhodococcus sp.Genome Announcements
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Genome and phenotype microarray analyses of rhodococcus sp. BCP1 and rhodococcus opacus R7: Genetic determinants and metabolic abilities with environ…

2015

In this paper comparative genome and phenotype microarray analyses of Rhodococcus sp. BCP1 and Rhodococcus opacus R7 were performed. Rhodococcus sp. BCP1 was selected for its ability to grow on short-chain n-alkanes and R. opacus R7 was isolated for its ability to grow on naphthalene and on o-xylene. Results of genome comparison, includ- ing BCP1, R7, along with other Rhodococcus reference strains, showed that at least 30% of the genome of each strain presented unique sequences and only 50% of the predicted proteome was shared. To associate genomic features with metabolic capabilities of BCP1 and R7 strains, hundreds of different growth conditions were tested through Phenotype Microarray, b…

AROMATIC-COMPOUNDS; GENUS RHODOCOCCUS; HIGH-THROUGHPUT; PATHWAY; DEGRADATION; BIODEGRADATION; EQUI; PERFORMANCE; CATABOLISMGenomics RhodococcusGene predictionBacterial Proteinlcsh:MedicineBiologyGenomeXenobioticsRhodococcus opacusBacterial ProteinsRhodococcuslcsh:ScienceGenePhylogenyGeneticsComparative genomicsMultidisciplinarylcsh:RMetabolic Networks and PathwayPhenotype microarrayHigh-Throughput Nucleotide SequencingRhodococcus sp. BCP1 Rhodococcus opacus R7Genome analysisGene Expression Regulation BacterialGenomicsSequence Analysis DNAbiology.organism_classificationBIO/19 - MICROBIOLOGIA GENERALEBiodegradation EnvironmentalPhenotypeProteomeGenomiclcsh:QPhenotype MicroarrayRhodococcusMetabolic Networks and PathwaysRhodococcuhydrocarbon degradationResearch Article
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Serum BPIFB4 levels classify health status in long-living individuals

2015

Background People that reach extreme ages (Long-Living Individuals, LLIs) are object of intense investigation for increase/decrease of genetic variant frequencies, genetic methylation levels, protein abundance in serum and tissues. The aim of these studies is the discovery of the mechanisms behind LLIs extreme longevity and the identification of markers of well-being. We have recently associated a BPIFB4 haplotype (LAV) with exceptional longevity under a homozygous genetic model, and identified that CD34+ of LLIs subjects express higher BPIFB4 transcript as compared to CD34+ of control population. It would be of interest to correlate serum BPIFB4 protein levels with exceptional longevity an…

AgingbiologyResearchmedia_common.quotation_subjectBPIFB4Disease progressionHaplotypeImmunologyBPIFB4; CD34; Methylation; Vascular ageingLongevityMethylationClinical nutritionVascular ageingMethylationAgeingImmunologyExtreme longevity trackingGenetic modelbiology.proteinCD34Antibodymedia_commonImmunity & Ageing
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