0000000000248050

AUTHOR

Mark P. Kühnel

showing 2 related works from this author

The bronchial circulation in COVID-19 pneumonia.

2021

American journal of respiratory and critical care medicine : AJRCCM 205(1), 121-125 (2022). doi:10.1164/rccm.202103-0594IM

Pulmonary and Respiratory Medicine2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)bronchial circulationRespiratory SystemCritical Care and Intensive Care Medicine03 medical and health sciences0302 clinical medicineMedicinepneumoniaIntussusceptive angiogenesis11 Medical and Health Sciencesintussusceptive angiogenesisbusiness.industryCOVID-19Bronchial circulationhierarchial phase-contrast tomographymedicine.disease3. Good healthPneumonia030228 respiratory systemImmunologyHuman medicinebusiness030217 neurology & neurosurgery
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The Adult Sprague-Dawley Sugen-Hypoxia Rat Is Still "the One:" A Model of Group 1 Pulmonary Hypertension: Reply to Le Cras and Abman

2020

To the editor: Kojonazarov et al. recently reported severe emphysema in the SU5416/Hypoxia (SuHx) rat model of pulmonary hypertension (1). The authors found that adult male Wistar Kyoto (WKY) rats had increased air-to-tissue ratio as judged by non-gated in vivo micro-computed tomography (CT), and an increased mean linear intercept (MLI) as surrogate of emphysema (1, 2). Le Cras and Abman now responded to the Kojonazarov report by underlining the “important role of the developmental timing of disrupted VEGF signaling” (3). They cite earlier studies conducted on the ovine fetus showing that VEGF inhibition caused vascular remodeling, reduction in vascular/airway growth, and neonatal pulmonary…

Pulmonary and Respiratory MedicineEmphysema0303 health sciencesIndolesbusiness.industryHypertension PulmonaryHypoxia (medical)Critical Care and Intensive Care Medicinemedicine.diseasePulmonary hypertensionRatsSprague dawleyRats Sprague-Dawley03 medical and health sciences0302 clinical medicine030228 respiratory systemAnesthesiaCorrespondenceMedicineAnimalsPyrrolesmedicine.symptombusinessHypoxia030304 developmental biology
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